Department of Internal Medicine-Division of Hematology-Oncology, American University of Beirut Medical Center, Riad El Solh, Beirut 1107 2020, Lebanon.
Department of Anatomy, Cell Biology and Physiology, American University of Beirut, Beirut 1107 2020, Lebanon.
Int J Mol Sci. 2018 Sep 13;19(9):2752. doi: 10.3390/ijms19092752.
Given the safety and potential benefits of intravenous ascorbic acid (AA) administration in cancer patients, there is merit in further exploring this therapeutic concept. In this review, we discuss the potential benefits of intravenous AA administration on colorectal cancer and we specifically focus on its effect on glycolysis in mutant and wild type . We perform a PubMed and Ovid MEDLINE search using ascorbic acid, intravenous vitamin C, mutation, mutation and colorectal cancer (CRC) as keywords. At the cellular level, colorectal cancer cells undergo a metabolic shift called the Warburg effect to allow for more glucose absorption and utilization of glycolysis. This shift also allows AA to enter which leads to a disruption in the Warburg effect and a shutdown of the downstream pathway in mutated colon cancer cells. At the clinical level, AA is associated with tumour regression in advanced disease and improved tolerability and side effects of standard therapy. Based on these findings, we conclude that further clinical trials are needed on a larger scale to examine the therapeutic benefits of AA in colon cancer.
鉴于静脉内给予抗坏血酸 (AA) 在癌症患者中的安全性和潜在益处，进一步探索这一治疗概念是有价值的。在这篇综述中，我们讨论了静脉内给予 AA 对结直肠癌的潜在益处，并且特别关注其对突变型和野生型的糖酵解的影响。我们使用抗坏血酸、静脉内维生素 C、突变、突变和结直肠癌 (CRC) 作为关键词，在 PubMed 和 Ovid MEDLINE 上进行了搜索。在细胞水平上，结直肠癌细胞发生称为瓦博格效应的代谢转变，以允许更多的葡萄糖吸收和利用糖酵解。这种转变也允许 AA 进入，导致瓦博格效应的破坏和下游通路在突变型结肠癌细胞中的关闭。在临床水平上，AA 与晚期疾病的肿瘤消退以及标准治疗的耐受性和副作用的改善相关。基于这些发现，我们得出结论，需要进行更大规模的临床试验，以检查 AA 在结肠癌中的治疗益处。
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