托珠单抗在眼和眼眶炎性疾病治疗中的作用：一种有用的替代方法。
The role of tocilizumab in the treatment of inflammatory diseases of the eye and orbit: A useful alternative.
作者信息
Ruiz-Medrano J, Díaz-Valle D, Cuiña R, Gegúndez J A, Chhablani J, Majumder P D, Gutierrez-Bonet R
机构信息
Hospital Universitario Clínico San Carlos, Ophthalmology Unit, Madrid, Spain.
Hospital Universitario Clínico San Carlos, Ophthalmology Unit, Madrid, Spain.
出版信息
J Fr Ophtalmol. 2018 Oct;41(8):759-766. doi: 10.1016/j.jfo.2018.02.006. Epub 2018 Sep 11.
PURPOSE
With uveitis being one of the leading causes of blindness worldwide, biological therapies have arisen as an option for the treatment of refractory cases based on good results shown in clinical practice. The goal of this study is to provide a systematic review of current knowledge of the role and possible uses of tocilizumab in the field of ophthalmology.
MATERIALS AND METHODS
We performed a search for records reporting the use of tocilizumab for various diseases in MEDLINE (PubMed and OVID). We conducted an analysis of several individual studies and their reported individual patient data (82 eyes of 45 patients) published from 2011 to 2017.
CONCLUSIONS
Tocilizumab may prove to be an effective choice for the treatment of a variety of ocular conditions such as refractory uveitis, inflammatory macular edema, vitreo-retinal tumors and thyroid orbitopathy, leading to control of the inflammation in these patients. Further studies need to be conducted to establish its safety and efficacy.
目的
葡萄膜炎是全球失明的主要原因之一，基于临床实践中显示的良好效果，生物疗法已成为治疗难治性病例的一种选择。本研究的目的是对托珠单抗在眼科领域的作用和可能用途的现有知识进行系统综述。
材料与方法
我们在MEDLINE（PubMed和OVID）中搜索了报告托珠单抗用于各种疾病的记录。我们对2011年至2017年发表的几项个体研究及其报告的个体患者数据（45例患者的82只眼）进行了分析。
结论
托珠单抗可能被证明是治疗多种眼部疾病（如难治性葡萄膜炎、炎性黄斑水肿、玻璃体视网膜肿瘤和甲状腺眼病）的有效选择，可控制这些患者的炎症。需要进一步研究以确定其安全性和有效性。
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