INSERM SC10-US19, Villejuif, France.
INSERM CIC 1417, Paris, France.
J Acquir Immune Defic Syndr. 2018 Oct 1;79 Suppl 1:S37-S50. doi: 10.1097/QAI.0000000000001807.
From 1992 to 2007, the ANRS (France Recherche Nord & Sud Sida-HIV Hépatites) set up a network of healthy volunteers at low risk of HIV infection and participating in preventive HIV vaccine phase I and II trials. The objectives of the ANRS COHVAC volunteer cohort include the social consequences of trial participation and their sexual behavior over time. For 488 volunteers who received a vaccine candidate, 462 selection files were collected, and from 2008 to 2016, 355 volunteers participated in the prospective cohort, including self-administered and face-to-face questionnaires administered annually. The volunteer population is relatively old, with social characteristics and engagement in society rather high. Most volunteers and people around them well accepted the trials, and participation in vaccine trials was not followed by increased risk-taking regarding HIV infection years later.
从 1992 年到 2007 年，法国研究南北艾滋病病毒肝炎协会（ANRS）建立了一个由感染艾滋病毒风险低的健康志愿者组成的网络，他们参与了预防艾滋病毒疫苗 I 期和 II 期试验。ANRS COHVAC 志愿者队列的目标包括试验参与的社会后果及其随时间推移的性行为。对于 488 名接种候选疫苗的志愿者，收集了 462 份选择文件，2008 年至 2016 年期间，355 名志愿者参加了前瞻性队列研究，包括每年进行的自我管理和面对面问卷调查。志愿者人群相对较老，具有较高的社会特征和参与社会的程度。大多数志愿者及其周围的人都很好地接受了试验，而且多年后，参与疫苗试验并没有导致感染艾滋病毒的风险增加。
