Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, Italy.
Department of Health Science, University Magna Grecia, 88100 Catanzaro, Italy.
Nutrients. 2018 Sep 14;10(9):1305. doi: 10.3390/nu10091305.
Epidemiological studies show that fruit consumption may modulate bone mineral density. However, data regarding the effect of the Risso (Bergamot orange), a citrus fruit containing a high concentration of flavonoids, on bone health are still lacking. In this study, we investigated the effects of Bergamot polyphenols on the Wnt/β-catenin pathway in two distinct bone cell types (Saos-2 and MG63). Findings showed that exposure to 0.01 and 0.1 mg/mL doses upregulate β-catenin expression ( = 0.001), osteoblast differentiation markers (e.g., and ), and downregulate RANKL ( = 0.028), as compared to the control. Our results highlight, for the first time, that Bergamot polyphenols act on bone cells through the β-catenin pathway. In vivo studies are necessary to fully understand Bergamot's role against bone resorption.
流行病学研究表明，水果的摄入可能会调节骨密度。然而，关于富含类黄酮的柑橘类水果 Risso（佛手柑）对骨骼健康的影响的数据仍然缺乏。在这项研究中，我们研究了佛手柑多酚对两种不同的骨细胞类型（Saos-2 和 MG63）中 Wnt/β-连环蛋白通路的影响。结果表明，与对照组相比，暴露于 0.01 和 0.1mg/ml 剂量下可上调β-连环蛋白表达（=0.001）、成骨分化标志物（如和 ），并下调 RANKL（=0.028）。我们的结果首次强调了佛手柑多酚通过β-连环蛋白通路作用于骨细胞。需要进行体内研究来充分了解佛手柑对骨吸收的作用。
Zotero 插件
