Narang Tarun, Vinay Keshavamurthy, Kumar Sheetanshu, Dogra Sunil
Lepr Rev. 2016 Dec;87(4):456-63.
Clinical data on pure-neuritic leprosy (PNL) is limited.
To study the clinical and epidemiological features of PNL in the leprosy post-elimination era.
This was a retrospective analysis of the clinic records of leprosy patients from January 2006 to June 2013. Data regarding age, sex, disease duration, presenting complaints, nerves affected, complications and treatment received were extracted from PNL cases.
Among 906 registered leprosy cases, 48 (5·3%) were found to have PNL. The mean age was 36·9 ± 16·2 years and predominantly males were affected (85·4%). The mean delay between onset of symptoms and diagnosis was 2·1 ± 2·2 years. Multiple nerves were affected in 36 patients (75%) and 12 (25%) had only one nerve involved. Visible deformities at presentation were noted in 32 (66·7%) patients. Forty patients (83·3%) were treated with multi drug therapy-multibacillary (MDTMB) regimen and three (6·25%) were treated with MDT-paucibacillary regimen. Twenty-one patients (43·8%) were considered positive responders to treatment. There was no correlation between the duration of NFI and treatment outcome.
PNL continues to occur in the post-elimination era. Grade 2 deformities are common in PNL compared to other leprosy patients because of delayed diagnosis and treatment. Distinct diagnosis and treatment guidelines and sensitisation of health care workers and physicians to the occurrence of PNL is the need of the day.
关于纯神经炎型麻风（PNL）的临床数据有限。
研究麻风消除时代PNL的临床和流行病学特征。
这是一项对2006年1月至2013年6月期间麻风患者临床记录的回顾性分析。从PNL病例中提取有关年龄、性别、病程、主诉、受累神经、并发症及接受治疗等数据。
在906例登记的麻风病例中，发现48例（5.3%）患有PNL。平均年龄为36.9±16.2岁，主要为男性受累（85.4%）。症状出现至诊断的平均延迟时间为2.1±2.2年。36例患者（75%）有多条神经受累，12例（25%）仅有一条神经受累。32例（66.7%）患者就诊时可见畸形。40例患者（83.3%）接受多药联合治疗 - 多菌型（MDTMB）方案治疗，3例（6.25%）接受少菌型MDT方案治疗。21例患者（43.8%）被认为对治疗有反应。神经炎持续时间与治疗结果之间无相关性。
在消除时代PNL仍有发生。与其他麻风患者相比，PNL患者二级畸形常见，原因是诊断和治疗延迟。明确的诊断和治疗指南以及提高医护人员和医生对PNL发生的认识是当务之急。
