14-3-3ζ/SOS1复合物的蛋白质X射线晶体学
Protein X-ray crystallography of the 14-3-3ζ/SOS1 complex.
作者信息
Ballone Alice, Centorrino Federica, Wolter Madita, Ottmann Christian
机构信息
Department of Biomedical Engineering, Eindhoven University of Technology, Laboratory of Chemical Biology, Eindhoven, 5600 MB, The Netherlands.
Department of Chemistry, University of Duisburg-Essen, Universitätsstr. 7, 45117 Essen, Germany.
出版信息
Data Brief. 2018 Jun 28;19:1683-1687. doi: 10.1016/j.dib.2018.06.060. eCollection 2018 Aug.
Activation of Ras-MAPK signaling regulates essential cellular functions; its aberration leads to irregular cell proliferation and differentiation (i.e. pancreatic cancer). Previously, it was revealed that the formation of the complex of the 14-3-3 protein and the Son of sevenless homolog 1 (SOS1) - one of the main actors of the Ras-MAPK cascade -, would represent a key-process to downstream the deviant Ra-MAPK signaling. In this data article we attempt to shed some light on the 3D structure, providing useful details about the crystallization process of the 14-3-3ζ dimer in complex with the 13-mer SOS1pS. The crystal structure is deposited at the Protein Data Bank with identifier 6F08. This Data in Brief article refers to "Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1) (2018)."
Ras-MAPK信号通路的激活调节着细胞的基本功能；其异常会导致细胞增殖和分化异常（如胰腺癌）。此前有研究表明，14-3-3蛋白与七号染色体失活同源物1（SOS1）（Ras-MAPK级联反应的主要参与者之一）形成复合物，是异常Ra-MAPK信号向下游传导的关键过程。在这篇数据文章中，我们试图阐明其三维结构，提供有关14-3-3ζ二聚体与13聚体SOS1pS复合物结晶过程的有用细节。该晶体结构已存入蛋白质数据库，标识符为6F08。这篇简短数据文章参考了“14-3-3ζ与人类七号染色体失活同源物1（SOS1）复合物的结构表征（2018年）”。
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