拟生源合成在 Tricholoma sciodes 生物碱 sciodole 中存在的双吲哚骨架。

Biomimetic synthesis of the bisindole framework present in sciodole, an alkaloid from Tricholoma sciodes.

机构信息

School of Chemical Sciences, 23 Symonds Street, University of Auckland, Auckland, New Zealand.

出版信息

Org Biomol Chem. 2018 Oct 3;16(38):6882-6885. doi: 10.1039/c8ob02142b.

Abstract

A synthesis of the unique bisindole framework present in the mushroom-derived alkaloid sciodole has been achieved, validating a biosynthesis proposal that the C-N bisindole bond present in the natural product is forged by amination of an azafulvenium.

摘要

已经实现了来源于蘑菇的生物碱石蒜裂碱中独特双吲哚骨架的综合，验证了天然产物中存在的 C-N 双吲哚键是通过氮杂福烯的胺化作用形成的生物合成假说。