HIV 感染中的抗体依赖的细胞细胞毒性。
Antibody-dependent cellular cytotoxicity in HIV infection.
机构信息
Division of Infectious Diseases, Department of Medicine, School of Medicine.
Department of Molecular Biology & Biochemistry, School of Biological Sciences, University of California, Irvine, USA.
出版信息
AIDS. 2018 Nov 13;32(17):2439-2451. doi: 10.1097/QAD.0000000000002011.
Abstract
: Interactions between the Fc segment of IgG and its receptors (FcγRs) found on cells such as natural killer cells, monocytes, macrophages and neutrophils can potentially mediate antiviral effects in the setting of HIV and related infections. We review the potential role of FcγR interactions in HIV, SIV and SHIV infections, with an emphasis on antibody-dependent cellular cytotoxicity (ADCC). Notably, these viruses employ various strategies, including CD4 down-regulation and BST-2/tetherin antagonism to limit the effect of ADCC. Although correlative data suggest that ADCC participates in both protection and control of established infection, there is little direct evidence in support of either role. Direct evidence does, however, implicate an FcγR-dependent function in augmenting the beneficial in vivo activity of neutralizing antibodies.
摘要
: IgG 的 Fc 片段与其在细胞（如自然杀伤细胞、单核细胞、巨噬细胞和中性粒细胞）上的受体（FcγRs）之间的相互作用可能在 HIV 和相关感染的情况下介导抗病毒作用。我们综述了 FcγR 相互作用在 HIV、SIV 和 SHIV 感染中的潜在作用，重点关注抗体依赖性细胞毒性（ADCC）。值得注意的是，这些病毒采用了多种策略，包括 CD4 下调和 BST-2/ tetherin 拮抗作用，以限制 ADCC 的效果。虽然相关数据表明 ADCC 参与了对已建立感染的保护和控制，但几乎没有直接证据支持任何一种作用。然而，直接证据表明 FcγR 依赖性功能增强了中和抗体的有益体内活性。
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