School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.
Lancet Child Adolesc Health. 2018 Oct;2(10):755-764. doi: 10.1016/S2352-4642(18)30245-1. Epub 2018 Sep 1.
Intrauterine growth restriction (IUGR) is often the result of compromised placental function and suboptimal uteroplacental blood flow. Children born with IUGR have impaired cognitive functioning and specific memory deficits, indicating long-lasting impairments in hippocampal functioning; indeed, hippocampal volume is reduced in infants with IUGR. Animal studies have provided valuable insight into the nature of deficits in hippocampal-dependent functions observed in children born with IUGR; outcomes of experimental IUGR reveal reduced neuron numbers and morphological alterations in the cornu ammonis fields 1 and 3 and dentate gyrus subregions of the hippocampus. However, whether such early and ongoing structural changes in the hippocampus could account for deficits in spatial memory reported in adolescent rats with IUGR is yet to be established. Understanding the association between hippocampal structural and functional alterations in IUGR will aid in the development of interventions to minimise the effect of IUGR on the hippocampus and long-term cognitive outcomes.
宫内生长受限（IUGR）通常是胎盘功能受损和子宫胎盘血流不足的结果。患有 IUGR 的儿童认知功能受损，存在特定的记忆缺陷，表明海马功能存在长期损害；事实上，IUGR 婴儿的海马体积减小。动物研究为理解 IUGR 儿童中海马依赖功能缺陷的本质提供了有价值的见解；实验性 IUGR 的结果显示，海马的齿状回和Cornu ammonis 场 1 和 3 的神经元数量减少和形态改变。然而，海马中这种早期和持续的结构变化是否可以解释 IUGR 青少年大鼠报告的空间记忆缺陷，还有待确定。了解 IUGR 中海马结构和功能改变之间的关联将有助于制定干预措施，以尽量减少 IUGR 对海马和长期认知结果的影响。
