[肢体淋巴水肿的带血管蒂淋巴结转移术研究进展]
[Research progress of vascularized lymph node transfer for extremity lymphedema].
作者信息
Qian Youlei, Yang Kai, Mu Lan
机构信息
Department of Plastic & Medical Aesthetic Surgery, Peking University People's Hospital, Beijing, 100034, P.R.China.
Department of Plastic & Medical Aesthetic Surgery, Peking University People's Hospital, Beijing, 100034,
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Aug 15;32(8):979-983. doi: 10.7507/1002-1892.201801069.
OBJECTIVE
To review the current progress of clinical and experimental research of vascularized lymph node transfer for lymphedema.
METHODS
The domestic and abroad literature about vascularized lymph node transfer in treatment of lymphedema was reviewed and analyzed.
RESULTS
Experimental studies in animal model indicate that vascularized lymph node transfer can improve lymph node survival and show a promising effectiveness in reducing lymphedema. "Lymphatic wick" and "lymph pump" were the two main hypotheses proposed to explain the potential functional mechanism of vascularized lymph node transfer in treatment of lymphedema. Improvement in lymphedema symptoms are reported in most of the clinical trials, but the level of evidence to advocate this procedure in the treatment of lymphedema remains low because of the small number of the cases and problems in their methodologies.
CONCLUSION
Based on current evidence, vascularized lymph node transfer seems to be a promising treatment for lymphedema, but long-term well-designed studies are required to further explore the effectiveness of this procedure.
目的
回顾带血管蒂淋巴结转移治疗淋巴水肿的临床及实验研究进展。
方法
对国内外关于带血管蒂淋巴结转移治疗淋巴水肿的文献进行回顾与分析。
结果
动物模型实验研究表明，带血管蒂淋巴结转移可提高淋巴结存活率，在减轻淋巴水肿方面显示出良好效果。“淋巴引流管”和“淋巴泵”是解释带血管蒂淋巴结转移治疗淋巴水肿潜在功能机制的两个主要假说。大多数临床试验均报告了淋巴水肿症状有所改善，但由于病例数量少及其方法学存在问题，主张该方法用于治疗淋巴水肿的证据水平仍然较低。
结论
基于目前的证据，带血管蒂淋巴结转移似乎是一种有前景的淋巴水肿治疗方法，但需要长期设计良好的研究来进一步探索该方法的有效性。
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