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使用可吸收植入物进行掌骨干骨折的手术固定:文献系统综述

Surgical Fixation of Metacarpal Shaft Fractures Using Absorbable Implants: A Systematic Review of the Literature.

作者信息

Hazan Jessica, Azzi Alain Joe, Thibaudeau Stephanie

机构信息

1 Faculty of Medicine, McGill University, Montreal, QC, Canada.

2 Division of Plastic & Reconstructive Surgery, McGill University, Faculty of Medicine, Montreal, QC, Canada.

出版信息

Hand (N Y). 2019 Jan;14(1):19-26. doi: 10.1177/1558944718798856. Epub 2018 Sep 21.

Abstract

BACKGROUND

Despite the proven efficacy and advantages of absorbable implants, their use for metacarpal shaft fixation has been limited. This is likely due to the high reported complication rates in early studies with polyglycolic acid (PGA) implants, notably high rates of noninfectious inflammatory reaction (5%-25%), occurring up to 30 weeks after fixation. The objective of this study was to assess the clinical outcomes of newer absorbable plates and screws in the treatment of metacarpal shaft fractures.

METHODS

The authors performed a systematic search of the PubMed, Ovid MEDLINE, and EMBASE databases dating from 1946 to 2017. Primary outcome measures were the development of noninfectious inflammatory reaction and implant failure.

RESULTS

A total of 42 metacarpal shaft fractures in 35 patients were included. The average follow-up time was 20.4 months (n = 24; range: 3.6-61 months). Only 1 case (2.4%) of noninfectious inflammatory reaction was reported with polylactic acid (PLA) plates and PLA/PGA compounds. Noninfectious inflammatory reaction was observed in 4 out of the 9 patients (44.4%) with a trimethylene carbonate/PLA compound. Symptoms appeared after an average time of 15.8 months (range: 12-19 months) post-fixation. Painless prolonged inflammation that resolved spontaneously within 6 months was reported in 7.1% of cases (n = 3). Implant failure with loss of fracture reduction was reported in 9.5% of cases (n = 4).

CONCLUSIONS

Newer absorbable materials appear to have significantly lower rates of noninfectious inflammatory reaction than previously reported. When compared with metallic fixation of the metacarpal shaft, absorbable fixation appears to have comparable complication rates and biomechanical properties.

摘要

背景

尽管可吸收植入物已被证实具有疗效和优势,但其在掌骨干固定中的应用一直有限。这可能是由于早期聚乙醇酸(PGA)植入物研究中报道的高并发症发生率,尤其是高达30周后出现的高非感染性炎症反应率(5%-25%)。本研究的目的是评估新型可吸收钢板和螺钉治疗掌骨干骨折的临床疗效。

方法

作者对1946年至2017年的PubMed、Ovid MEDLINE和EMBASE数据库进行了系统检索。主要观察指标为非感染性炎症反应的发生情况和植入物失败情况。

结果

共纳入35例患者的42例掌骨干骨折。平均随访时间为20.4个月(n = 24;范围:3.6-61个月)。聚乳酸(PLA)钢板和PLA/PGA复合材料仅报告了1例(2.4%)非感染性炎症反应。9例使用碳酸三亚甲基酯/PLA复合材料的患者中有4例(44.4%)观察到非感染性炎症反应。症状出现在固定后平均15.8个月(范围:12-19个月)。7.1%的病例(n = 3)报告有无痛性长期炎症,在6个月内自行消退。9.5%的病例(n = 4)报告了植入物失败伴骨折复位丢失。

结论

新型可吸收材料的非感染性炎症反应率似乎明显低于先前报道。与掌骨干金属固定相比,可吸收固定的并发症发生率和生物力学性能似乎相当。

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