鼻腔内催产素和 OXTR 基因型对静息态功能连接的影响：系统综述。
Intranasal oxytocin and OXTR genotype effects on resting state functional connectivity: A systematic review.
机构信息
Department of Psychology, University of Arizona, Tucson, AZ, USA.
Department of Psychology, University of Arizona, Tucson, AZ, USA.
出版信息
Neurosci Biobehav Rev. 2018 Dec;95:17-32. doi: 10.1016/j.neubiorev.2018.09.011. Epub 2018 Sep 19.
OBJECTIVE
Evaluate effects of intranasal oxytocin (IN-OT) and OXTR genotype on resting state functional connectivity in the human brain.
METHODS
We searched research databases for peer-reviewed empirical studies. Of 71 unique citations, 18 articles (13 IN-OT, five OXTR) met full inclusion criteria.
RESULTS
Two studies examined effects on large-scale networks; most examined acute effects on amygdala connectivity with other social and affective regions. OXTR studies identified three polymorphisms (rs2254298, rs2268498, rs53576) having allele- and sex-dependent effects on prefrontal functional connectivity, and additive effects of OXTR risk alleles on reward circuitry. Age, sex, early life stress, and psychopathology emerged as potential moderators of both IN-OT and OXTR effects.
DISCUSSION
IN-OT appears to modulate resting state functional connectivity in a manner similar to its effects on task fMRI, consistent with hypothesized models of IN-OT. However, conclusions are limited by the narrow range of neuroanatomical seed regions, and methodological and experimental design heterogeneity. Future studies should take into account individual differences. Findings may provide insight into mechanisms through which IN-OT impacts human behavior.
目的
评估鼻内催产素（IN-OT）和 OXTR 基因型对人脑静息状态功能连接的影响。
方法
我们在同行评审的实证研究数据库中搜索研究文献。在 71 条独特的引文中有 18 篇文章（13 篇 IN-OT，5 篇 OXTR）符合全部纳入标准。
结果
两项研究检验了对大尺度网络的影响；大多数研究检验了催产素对杏仁核与其他社会和情感区域的连接的急性影响。OXTR 研究确定了三个多态性（rs2254298、rs2268498、rs53576），它们对前额叶功能连接具有等位基因和性别依赖性影响，并且 OXTR 风险等位基因对奖励回路具有累加效应。年龄、性别、早期生活应激和精神病理学是 IN-OT 和 OXTR 效应的潜在调节因素。
讨论
IN-OT 似乎以类似于其对任务 fMRI 的影响的方式调节静息状态功能连接，这与 IN-OT 的假设模型一致。然而，结论受到神经解剖学种子区域范围狭窄以及方法学和实验设计异质性的限制。未来的研究应考虑个体差异。这些发现可能为 IN-OT 影响人类行为的机制提供了一些见解。
Zotero 插件