Brusch George A, DeNardo Dale F
Arizona State University, School of Life Sciences, 427 East Tyler Mall, Tempe, AZ, 85281, USA.
Arizona State University, School of Life Sciences, 427 East Tyler Mall, Tempe, AZ, 85281, USA.
Dev Comp Immunol. 2019 Jan;90:147-151. doi: 10.1016/j.dci.2018.09.013. Epub 2018 Sep 19.
The immune system is essential for survival and its performance can vary depending on the physiological state of the organism. Much of the current research into immune function dynamics has examined newborn to adult life stages, despite previous studies documenting physiological responses in embryos to environmental stimuli. While energy balance has been the predominant focus as the driver of changes in immune function, recent research has found a positive relationship between dehydration and innate immune performance in adult reptiles. We expanded the understanding of this relationship by examining trans-generational immune effects of female dehydration as well as the effects of egg desiccation on embryonic hydration state and innate immunity using Children's pythons, Antaresia childreni. We used a 2 × 2 experiment with hydrated or dehydrated mothers and eggs either incubated under continuous optimal conditions or experiencing desiccating conditions for 24 h. Our results demonstrate that, similar to adults, embryos enhance some metrics of innate immunity when they are dehydrated.
免疫系统对生存至关重要，其功能表现会因生物体的生理状态而异。尽管先前有研究记录了胚胎对环境刺激的生理反应，但目前对免疫功能动态的许多研究都集中在从新生儿到成年的生命阶段。虽然能量平衡一直是免疫功能变化的主要驱动因素，但最近的研究发现脱水与成年爬行动物的先天免疫表现之间存在正相关关系。我们通过研究雌性脱水的跨代免疫效应以及卵干燥对胚胎水合状态和先天免疫的影响，利用儿童蟒（Antaresia childreni）扩展了对这种关系的理解。我们采用了一个2×2实验，即分别用处于水合或脱水状态的母体，以及在持续最佳条件下孵化或经历24小时干燥条件的卵。我们的结果表明，与成年个体类似，胚胎在脱水时会增强先天免疫的某些指标。
