Basnet Rajesh, Gong Grace Qun, Li Chenyao, Wang Ming-Wei
The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Acta Pharm Sin B. 2018 Sep;8(5):767-771. doi: 10.1016/j.apsb.2018.07.001. Epub 2018 Jul 5.
The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer.
血清和糖皮质激素诱导蛋白激酶（SGK）家族成员与AKT以及磷脂酰肌醇3激酶（PI3K）信号通路下游的信号具有相似的结构、底物特异性和功能。它们调节一系列基本的细胞过程，如细胞增殖和存活，从而在癌症发展中发挥重要作用。本文旨在概述SGK（特别是SGK3）在癌症进展中的作用，并比较SGK3和AKT在细胞周期调控、致癌信号传导以及作为癌症治疗靶点的潜力。
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