Vogel F, Scherneck S, Rohde K
Biomed Biochim Acta. 1986;45(7):887-95.
Sequences with 2-fold axis of symmetry (inverted repeated sequences) have been detected and mapped on the hamster papovavirus (HaPV) genome by their ability to form secondary structures like hairpins or stem-loops on single-stranded HaPV DNA. DNA regions with secondary structure were visualized by electron microscopy and mapped according to the physical map of HaPV. Eleven positions containing inverted repeats could be determined. The nucleotide sequence within all of these inverted repeats may be related since these regions can crosshybridize with each other. The possible functions of these sequences within the HaPV genome are discussed with respect to conditions found for genomes like those from SV40 and polyoma virus to get first indications for the localization of DNA regions representing the origin and termination of replication of HaPV DNA.
通过在单链仓鼠乳头瘤病毒（HaPV）DNA上形成发夹或茎环等二级结构的能力，已检测到具有二重对称轴的序列（反向重复序列）并将其定位在HaPV基因组上。具有二级结构的DNA区域通过电子显微镜观察，并根据HaPV的物理图谱进行定位。可以确定11个含有反向重复序列的位置。所有这些反向重复序列中的核苷酸序列可能相关，因为这些区域可以相互交叉杂交。针对HaPV基因组中这些序列的可能功能，结合SV40和多瘤病毒基因组的情况进行了讨论，以便初步了解代表HaPV DNA复制起点和终点的DNA区域的定位。
