取代的 4-氯-3-硝基苯基硫脲衍生物：抗菌和细胞毒性研究。
Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies.
机构信息
Department of Biochemistry, Medical University, 02-097 Warszawa, Poland.
Department of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliary, Cittadella Universitaria, 09042 Monserrato, Italy.
出版信息
Molecules. 2018 Sep 21;23(10):2428. doi: 10.3390/molecules23102428.
4-Chloro-3-nitrophenylthioureas ⁻ were synthesized and tested for their antimicrobial and cytotoxic activities. Compounds exhibited high to moderate antistaphylococcal activity against both standard and clinical strains (MIC values 2⁻64 μg/mL). Among them derivatives with electron-donating alkyl substituents at the phenyl ring were the most promising. Moreover, compounds ⁻ and ⁻ were cytotoxic against MT-4 cells and various other cell lines derived from human hematological tumors (CC ≤ 10 μM). The influence of derivatives , and on viability, mortality and the growth rate of immortalized human keratinocytes (HaCaT) was observed.
4-氯-3-硝基苯基硫脲被合成并测试了其抗菌和细胞毒性活性。化合物对标准和临床分离株均表现出高至中度的抗葡萄球菌活性（MIC 值为 2⁻64 μg/mL）。其中，苯环上带有供电子烷基取代基的衍生物最有前景。此外，化合物 ⁻ 和 ⁻ 对 MT-4 细胞和源自人血液肿瘤的各种其他细胞系具有细胞毒性（CC ≤ 10 μM）。观察了衍生物 ⁻、 ⁻ 和 ⁻ 对永生化人角质形成细胞（HaCaT）活力、死亡率和增长率的影响。
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