Kimura Yusuke, Harada Takashi, Sasaki Takafumi, Imai Tomoko, Machida Noboru
Laboratory of Veterinary Clinical Oncology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Heart Animal Clinic, 1-7-13 Maedaminami-cho, Toyohashi, Aichi 440-0851, Japan.
J Vet Med Sci. 2018 Nov 23;80(11):1716-1719. doi: 10.1292/jvms.18-0272. Epub 2018 Sep 21.
A 10-week-old miniature dachshund presented with acute onset of weakness. Electrocardiography showed sustained ventricular tachycardia, and thoracic and abdominal radiography revealed pleural and peritoneal effusion. Echocardiography revealed severely hypokinetic left and right ventricles. Thoracocentesis and abdominocentesis and subsequent transfer to an oxygen chamber yielded no clinical improvement, and the dog died about 1 hr after admission. Gross examination of a longitudinal section through the entire heart revealed poorly demarcated focal or patchy areas of grayish-white tissue infiltrating extensively into the myocardium. Histologically, these lesions were consistent with infiltrative proliferation of neoplastic lymphoid cells. Immunohistochemical staining confirmed the diagnosis of primary cardiac lymphoma (PCL) of T-cell origin. There have been no previous reports of such young dogs with PCL.
一只10周大的迷你腊肠犬出现急性虚弱症状。心电图显示持续性室性心动过速，胸部和腹部X线检查显示胸腔和腹腔积液。超声心动图显示左、右心室严重运动减弱。胸腔穿刺和腹腔穿刺，随后转移至氧气舱，病情未得到临床改善，该犬在入院后约1小时死亡。对整个心脏的纵切面进行大体检查，发现灰白色组织界限不清的局灶性或斑片状区域广泛浸润心肌。组织学上，这些病变与肿瘤性淋巴细胞的浸润性增殖一致。免疫组织化学染色证实为T细胞起源的原发性心脏淋巴瘤（PCL）。此前尚无如此年轻的PCL犬的报道。
