ADHFE1是一种与MYC相关的癌基因，可诱导乳腺癌中的代谢重编程和细胞去分化。
ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer.
作者信息
Mishra Prachi, Tang Wei, Ambs Stefan
机构信息
Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
出版信息
Mol Cell Oncol. 2018 Apr 19;5(3):e1432260. doi: 10.1080/23723556.2018.1432260. eCollection 2018.
The oncometabolite, -2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for -2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis.
肿瘤代谢物-2-羟基戊二酸因异柠檬酸脱氢酶1和2的获得性突变而在多种癌症中蓄积。在此，我们描述了乳腺癌中-2-羟基戊二酸蓄积的一种新机制。它涉及c-Myc信号传导以及含铁血黄素蛋白1的乙醇脱氢酶（ADHFE1），并导致代谢重编程、去分化以及乳腺肿瘤发生增加。
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