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德国睾丸癌指南的依从性及治疗模式:一项全国性调查。

Testicular cancer guideline adherence and patterns of care in Germany: A nationwide survey.

作者信息

Nestler Tim, Baunacke Martin, Dräger Desiree, von Landenberg Nicolas, Groeben Christer, Huber Johannes

机构信息

Department of Urology, Federal Armed Services Hospital Koblenz, Koblenz, Germany.

Department of Urology, University Hospital Dresden, Dresden, Germany.

出版信息

Eur J Cancer Care (Engl). 2019 Jan;28(1):e12917. doi: 10.1111/ecc.12917. Epub 2018 Sep 25.

Abstract

Testicular cancer has excellent cure rates; however, poor guideline adherence can lead to inappropriate management, with a detrimental effect on outcomes. Therefore, we aimed to investigate the current patterns of care for testicular cancer patients and to evaluate guideline adherence. A 19-item survey was distributed among German urologists between September 2015 and September 2016. The response rate was 45% (411/920). Staging imaging of the chest was performed by computed tomography (CT) in 85.5% and X-ray in 17.7%, and for the abdomen, by CT in 83.7% and by magnetic resonance imaging (MRI) in 21.1%. Areas of discrepancy with respect to guideline recommendations included underuse of MRI and infrequent follow-up examinations for changes in the cardiovascular, endocrine, neurological, and pulmonary systems, in addition to psychological burden. Further deviations of reported routine procedures from guideline recommendations were identified in the fields of active surveillance in Stage I seminoma, contralateral biopsies (63.1% overuse) and cryopreservation (19.2% underuse). Moreover, we found that hospital-based clinicians and younger specialists, with ≤5 years of practice following board certification, perform a more accurate and thorough follow-up. German urologists show relatively strong guideline adherence in staging patterns. Significant improvements are necessary in the following areas: recommending cryopreservation, imaging modalities and accurate follow-up examinations with a focus on late toxicities.

摘要

睾丸癌的治愈率很高;然而,对指南的依从性差可能导致管理不当,对治疗结果产生不利影响。因此,我们旨在调查睾丸癌患者当前的护理模式,并评估对指南的依从性。2015年9月至2016年9月期间,我们向德国泌尿科医生发放了一份包含19个项目的调查问卷。回复率为45%(411/920)。胸部分期成像采用计算机断层扫描(CT)的比例为85.5%,采用X线的比例为17.7%;腹部成像采用CT的比例为83.7%,采用磁共振成像(MRI)的比例为21.1%。与指南建议存在差异的方面包括MRI使用不足,以及心血管、内分泌、神经和肺部系统变化的随访检查不频繁,此外还有心理负担问题。在I期精原细胞瘤的主动监测、对侧活检(过度使用63.1%)和冷冻保存(使用不足19.2%)等领域,还发现报告的常规程序与指南建议存在进一步偏差。此外,我们发现,在获得委员会认证后执业年限≤5年的医院临床医生和年轻专家,进行的随访更准确、更全面。德国泌尿科医生在分期模式方面对指南的依从性相对较强。在以下方面有必要进行重大改进:推荐冷冻保存、成像方式以及针对晚期毒性的准确随访检查。

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