γ-氨基丁酸能将胰腺α细胞转化为β细胞吗？ - Suppr

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Can GABA turn pancreatic α-cells into β-cells?

作者信息

Eizirik Decio L, Gurzov Esteban N

机构信息

ULB Center for Diabetes Research, Universite Libre de Bruxelles (ULB), Brussels, Belgium.

出版信息

Nat Rev Endocrinol. 2018 Nov;14(11):629-630. doi: 10.1038/s41574-018-0101-6.

DOI:10.1038/s41574-018-0101-6

PMID:30254299

Abstract

摘要

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Can GABA turn pancreatic α-cells into β-cells?

作者信息

Eizirik Decio L, Gurzov Esteban N

机构信息

ULB Center for Diabetes Research, Universite Libre de Bruxelles (ULB), Brussels, Belgium.

出版信息

Nat Rev Endocrinol. 2018 Nov;14(11):629-630. doi: 10.1038/s41574-018-0101-6.

DOI:10.1038/s41574-018-0101-6

PMID:30254299

Abstract

摘要

相似文献

Can GABA turn pancreatic α-cells into β-cells?

Nat Rev Endocrinol. 2018 Nov;14(11):629-630. doi: 10.1038/s41574-018-0101-6.

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo.

Cell Metab. 2018 Nov 6;28(5):787-792.e3. doi: 10.1016/j.cmet.2018.07.002. Epub 2018 Jul 26.

Gimmicks of gamma-aminobutyric acid (GABA) in pancreatic β-cell regeneration through transdifferentiation of pancreatic α- to β-cells.

Cell Biol Int. 2020 Apr;44(4):926-936. doi: 10.1002/cbin.11302. Epub 2020 Jan 16.

Absence of spontaneous regeneration of endogenous pancreatic β-cells after chemical-induced diabetes and no effect of GABA on α-to-β cell transdifferentiation in rhesus monkeys.

Biochem Biophys Res Commun. 2019 Jan 22;508(4):1056-1061. doi: 10.1016/j.bbrc.2018.12.062. Epub 2018 Dec 13.

Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes.

Diabetologia. 2017 Jun;60(6):1033-1042. doi: 10.1007/s00125-017-4239-x. Epub 2017 Mar 9.

Glucagon-like peptide-1 promotes α-to-β cell transdifferentiation: How far is it from clinical application?

Diabetes Metab. 2019 Dec;45(6):601-602. doi: 10.1016/j.diabet.2019.01.003. Epub 2019 Jan 17.

Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.

Development. 2015 Apr 15;142(8):1407-17. doi: 10.1242/dev.117911.

Evolving function and potential of pancreatic alpha cells.

Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):859-71. doi: 10.1016/j.beem.2015.10.002. Epub 2015 Oct 8.

Role of transcription factors in the transdifferentiation of pancreatic islet cells.

J Mol Endocrinol. 2015 Apr;54(2):R103-17. doi: 10.1530/JME-14-0290.

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

Gastroenterology. 2010 May;138(5):1954-65. doi: 10.1053/j.gastro.2010.01.046. Epub 2010 Feb 2.

引用本文的文献

In Vitro and In Vivo Assessments of Anti-Hyperglycemic Properties of Soybean Residue Fermented with and .

Life (Basel). 2022 Oct 27;12(11):1716. doi: 10.3390/life12111716.

Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes?

Int J Mol Sci. 2021 Apr 19;22(8):4239. doi: 10.3390/ijms22084239.

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure.

Nat Rev Endocrinol. 2020 Jul;16(7):349-362. doi: 10.1038/s41574-020-0355-7. Epub 2020 May 12.

How, When, and Where Do Human β-Cells Regenerate?

Curr Diab Rep. 2019 Jun 27;19(8):48. doi: 10.1007/s11892-019-1176-8.