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宫腔内非肌瘤对体外受精-胚胎移植疗效影响的研究：一项更新的荟萃分析。

The Impact of Noncavity-Distorting Intramural Fibroids on the Efficacy of In Vitro Fertilization-Embryo Transfer: An Updated Meta-Analysis.

机构信息

The Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing 400016, China.

出版信息

Biomed Res Int. 2018 Sep 4;2018:8924703. doi: 10.1155/2018/8924703. eCollection 2018.

DOI:10.1155/2018/8924703
PMID:30255100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6142781/
Abstract

AIM

To address the impact of noncavity-distorting intramural fibroids on the efficacy of in vitro fertilization-embryo transfer (IVF-ET) outcomes.

METHODS

The PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure were searched systematically. A meta-analysis was performed based on comparative or cohort studies that explored the impact of noncavity-distorting intramural fibroids on the efficacy of IVF-ET treatment. The IVE-ET outcomes of study group (women with noncavity-distorting intramural fibroids) and control group (women without fibroids) were compared, including live birth rate (LBR), clinical pregnancy rate (cPR), implantation rate (IR) , miscarriage rate (MR), and ectopic pregnancy rate (ePR).

RESULTS

A total of 28 studies involving 9189 IVF cycles were included. Our meta-analysis showed a significant reduction of LBR in the study group compared to control group (RR = 0.82, 95% CI: 0.73-0.92, and P = 0.005). In addition, it indicated that study group had a significant reduction in cPR (RR = 0.86, 95% CI: 0.80-0.93, P = 0.0001) and IR (RR = 0.90, 95% CI: 0813-1.00, P = 0.04) and have a significantly increase in MR (RR = 1.27, 95% CI: 1.08-1.50, and P = 0.004) compared with control group.

CONCLUSIONS

The present evidence suggests that noncavity-distorting intramural fibroids would significantly reduce the IR, cRP, and LBR and significantly increase the MR after IVF treatment, but it would not significantly increase the ePR.

摘要

目的

探讨非宫腔内变形型子宫肌瘤对体外受精-胚胎移植（IVF-ET）结局的影响。

方法

系统检索 PubMed、Web of Science、Embase、Cochrane Library 和中国知网（CNKI），纳入比较或队列研究，评估非宫腔内变形型子宫肌瘤对 IVF-ET 治疗结局的影响。比较研究组（患有非宫腔内变形型子宫肌瘤的妇女）和对照组（无子宫肌瘤的妇女）的 IVF-ET 结局，包括活产率（LBR）、临床妊娠率（cPR）、着床率（IR）、流产率（MR）和宫外孕率（ePR）。

结果

共纳入 28 项研究，涉及 9189 个 IVF 周期。Meta 分析显示，与对照组相比，研究组的 LBR 显著降低（RR=0.82，95%CI：0.73-0.92，P=0.005）。此外，研究组的 cPR（RR=0.86，95%CI：0.80-0.93，P=0.0001）和 IR（RR=0.90，95%CI：0.813-1.00，P=0.04）显著降低，MR 显著升高（RR=1.27，95%CI：1.08-1.50，P=0.004）。

结论

现有证据表明，非宫腔内变形型子宫肌瘤会显著降低 IVF 治疗后的 IR、cPR 和 LBR，显著增加 MR，但不会显著增加 ePR。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/40b3855ba08f/BMRI2018-8924703.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/03689acd3910/BMRI2018-8924703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/806c1276769b/BMRI2018-8924703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/031189fb5033/BMRI2018-8924703.003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/b83624d398f5/BMRI2018-8924703.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/243c2bc3b448/BMRI2018-8924703.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/f1fe7cb21061/BMRI2018-8924703.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/5510443fec4d/BMRI2018-8924703.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/40b3855ba08f/BMRI2018-8924703.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/03689acd3910/BMRI2018-8924703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/806c1276769b/BMRI2018-8924703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/031189fb5033/BMRI2018-8924703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/99199ea73471/BMRI2018-8924703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/03c6d345a56e/BMRI2018-8924703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/b83624d398f5/BMRI2018-8924703.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/243c2bc3b448/BMRI2018-8924703.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/f1fe7cb21061/BMRI2018-8924703.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/5510443fec4d/BMRI2018-8924703.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3942/6142781/40b3855ba08f/BMRI2018-8924703.010.jpg

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