人 MX2/MxB：一种有效的干扰素诱导的疱疹病毒和 HIV-1 的进入后抑制剂。
Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1.
机构信息
Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany
Medical Faculty, University of Freiburg, Freiburg, Germany.
出版信息
J Virol. 2018 Nov 27;92(24). doi: 10.1128/JVI.00709-18. Print 2018 Dec 15.
Abstract
Interferons limit viral replication by inducing intracellular restriction factors, such as the GTPase MxB (also designated MX2), which inhibits HIV-1 and, as recently shown, herpesviruses. Inhibition of these viruses occurs at ill-defined steps after viral entry and requires formation of MxB dimers or oligomers, but GTP hydrolysis is needed only for blocking herpesviruses. Together with previous findings on related MxA, the new research on MxB highlights the mechanistic diversity by which MX proteins interfere with viral replication.
摘要
干扰素通过诱导细胞内限制因子来限制病毒复制，例如 GTPase MxB（也称为 MX2），它可以抑制 HIV-1，最近还显示可以抑制疱疹病毒。这些病毒的抑制作用发生在病毒进入后的不确定步骤中，需要形成 MxB 二聚体或寡聚体，但 GTP 水解仅对阻断疱疹病毒是必需的。结合以前关于相关 MxA 的研究结果，这项关于 MxB 的新研究强调了 MX 蛋白干扰病毒复制的机制多样性。
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