维生素 D 受体与 NLRP3 相互作用，限制过敏反应。
Vitamin D receptor interacts with NLRP3 to restrict the allergic response.
机构信息
Department of Gastroenterology, the Fifth Hospital, Zhengzhou University, Zhengzhou, China.
The Research Center of Allergy and Immunology, Shenzhen University Faculty of Medicine, Shenzhen, China.
出版信息
Clin Exp Immunol. 2018 Oct;194(1):17-26. doi: 10.1111/cei.13164. Epub 2018 Sep 9.
Vitamin D receptor (VDR) mediates various biochemical activities between the cytoplasm and the nucleus in the cell. The nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) protein is involved in the T helper type 2 (Th2) response. This study tests a hypothesis that VDR interacts with NLRP3 to restrict the Th2-biased response. In this study, VDR mice and WT (WT) mice were used. Th2 cell differentiation between VDR mice and WT mice was observed. We observed that CD4 T cell activation was higher in VDR mice. The VDRCD4 T cells were prone to Th2 polarization. VDR mice produced more immunoglobulin (Ig)E. VDR bound NLRP3 to prevent Th2 differentiation by restricting IL4 gene transcription. Th2 biased inflammation spontaneously developed in the intestine of VDR mice. In conclusion, VDR binds NLRP3 to restrict IL4 gene transcription and prevent biased Th2 polarization.
维生素 D 受体（VDR）介导细胞内细胞质和细胞核之间的各种生化活性。核苷酸结合寡聚化结构域（NOD）样受体家族，含 pyrin 结构域蛋白 3（NLRP3）参与辅助性 T 细胞 2（Th2）反应。本研究检验了一个假设，即 VDR 与 NLRP3 相互作用以限制 Th2 偏向反应。在这项研究中，使用了 VDR 小鼠和 WT（WT）小鼠。观察了 VDR 小鼠和 WT 小鼠之间 Th2 细胞分化。我们观察到 VDR 小鼠中 CD4 T 细胞的激活更高。VDRCD4 T 细胞容易发生 Th2 极化。VDR 小鼠产生更多的免疫球蛋白（Ig）E。VDR 结合 NLRP3 通过限制 IL4 基因转录来防止 Th2 分化。VDR 小鼠的肠道中自发出现 Th2 偏向性炎症。总之，VDR 结合 NLRP3 以限制 IL4 基因转录并防止 Th2 极化偏向。
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