高渗盐水吸入对健康成年人一氧化氮肺弥散量的急性影响。

Acute effects of hypertonic saline inhalation on nitric oxide pulmonary diffusing capacity in healthy adults.

机构信息

Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich, Ludwig-Maximilians-Universität, Munich, Germany; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Neuherberg, Germany.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland; Division of Occupational and Environmental Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

出版信息

Respir Physiol Neurobiol. 2018 Dec;258:40-46. doi: 10.1016/j.resp.2018.09.007. Epub 2018 Sep 24.

DOI:10.1016/j.resp.2018.09.007

PMID:30261306

Abstract

We investigated acute effects of inhalation of hypertonic saline solution (HSS) and oxygen (O, control exposure) on pulmonary diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO). In a randomized crossover study, 20 healthy, non-smoking subjects were allocated to short-term inhalation of HSS or O. Spirometry [(forced expiratory volume in 1 s (FEV) and forced vital capacity (FVC)] and combined single-breath DLNO-DLCO measurements were performed before and immediately after inhalation of either HSS or O. Percent changes were presented as median values (interquartile range). After HSS inhalation, DLNO, FEV and FVC were decreased by -3.0% (-7.3, 0.5), -3.1% (-4.2, -1.6) and -1.2% (-3.3, 0.6), respectively (all P < 0.05), without significant effect on DLCO. No changes in spirometry and diffusing capacity were observed following O inhalation. Acute inhalation of HSS causes a slight decrease in membrane conductance, probably as a result of fluid imbalance at the alveolar surface and interstitial fluid accumulation, both of which could impair gas exchange.

摘要

我们研究了吸入高渗盐水溶液（HSS）和氧气（O，对照暴露）对一氧化氮（DLNO）和一氧化碳（DLCO）肺弥散能力的急性影响。在一项随机交叉研究中，将 20 名健康、不吸烟的受试者分配到短期吸入 HSS 或 O。在吸入 HSS 或 O 之前和之后立即进行肺活量测定[1 秒用力呼气量（FEV）和用力肺活量（FVC）]和联合单次呼吸 DLNO-DLCO 测量。百分比变化以中位数（四分位间距）表示。吸入 HSS 后，DLNO、FEV 和 FVC 分别下降了-3.0%（-7.3，0.5）、-3.1%（-4.2，-1.6）和-1.2%（-3.3，0.6）（均 P<0.05），但对 DLCO 没有显著影响。吸入 O 后，肺活量测定和弥散能力没有变化。急性吸入 HSS 会导致膜电导略有下降，可能是肺泡表面液体失衡和间质液积聚的结果，这两者都可能损害气体交换。