C4d沉积在儿童免疫球蛋白A肾病中的临床相关性
Clinical Relevance of C4d Deposition in Pediatric Immunoglobulin A Nephropathy.
作者信息
Baek Hee Sun, Hoon Han Man, Jin Kim Yong, Hyun Cho Min
机构信息
a Department of Pediatrics, School of Medicine , Kyungpook National University , Daegu , Korea.
b Department of Pathology, School of Medicine , Kyungpook National University , Daegu , Korea.
出版信息
Fetal Pediatr Pathol. 2018 Oct;37(5):326-336. doi: 10.1080/15513815.2018.1504841. Epub 2018 Oct 1.
INTRODUCTION
Few studies have reported the association between the complement cascade and pediatric immunoglobulin A nephropathy (IgAN). This study aimed to investigate the association between C4d staining positivity and the clinical/histopathological characteristics of pediatric patients with IgAN.
METHODS
Children diagnosed with IgAN through renal biopsy were retrospectively reviewed. Renal biopsy specimens were stained using C4d immunohistochemistry.
RESULTS
Among the 56 patients, 31 (55.4%) showed positive mesangial or peripheral capillary C4d staining in glomeruli. Urine protein-to-creatinine ratio was significantly higher in C4d-positive patients (p = 0.001). The severity of mesangial proliferation according to the Haas and Oxford classification was positively associated with positive C4d staining (p < 0.001).
CONCLUSION
Positive C4d staining was found to be significantly associated with the clinical/histopathological severity of IgAN.
引言
很少有研究报道补体级联反应与儿童免疫球蛋白A肾病（IgAN）之间的关联。本研究旨在探讨C4d染色阳性与儿童IgAN患者临床/组织病理学特征之间的关联。
方法
对经肾活检诊断为IgAN的儿童进行回顾性研究。肾活检标本采用C4d免疫组织化学染色。
结果
56例患者中，31例（55.4%）肾小球系膜或外周毛细血管C4d染色呈阳性。C4d阳性患者的尿蛋白/肌酐比值显著更高（p = 0.001）。根据Haas和牛津分类法，系膜增生的严重程度与C4d染色阳性呈正相关（p < 0.001）。
结论
发现C4d染色阳性与IgAN的临床/组织病理学严重程度显著相关。
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