Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel; The Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, 52900, Israel.
InnoAging, Gershon Avner 13/16, Jerusalem, Israel.
Appetite. 2019 Jan 1;132:44-54. doi: 10.1016/j.appet.2018.09.023. Epub 2018 Sep 29.
Nitric Oxide (NO) and its precursor l-arginine were found to inhibit feeding in rats with a low motivation to eat, as they do in Aplysia. In rats that are relatively satiated, treatment with an NO blocker increased feeding, and treatment with an NO donor or with either of 2 doses of l-arginine inhibited feeding. NO and l-arginine modulated several parameters of feeding, such as the total duration of appetitive behaviors, the time spent feeding, the quantity of food eaten and the number of feeding bouts. The inhibitory effect of l-arginine on feeding could not be attributed to changes in locomotion. These data indicate that satiation is partially mediated by increased production of NO. NADPH-Diaphorase histochemical staining, which is specific for tissues actively producing NO, showed significantly greater staining in satiated compared to hungry rats in all 4 hypothalamic nuclei (paraventricular and arcuate nuclei, lateral and ventromedial hypothalamus) that were examined. l-arginine may act as a regulator of feeding by controlling NO production in several hypothalamic nuclei, specifically under condition of a low feeding motivation.
一氧化氮（NO）及其前体 l-精氨酸被发现可抑制进食动机较低的大鼠进食，就像在海兔中一样。在相对饱食的大鼠中，用 NO 阻断剂治疗会增加进食，而用 NO 供体或两种剂量的 l-精氨酸治疗则会抑制进食。NO 和 l-精氨酸调节了进食的几个参数，如进食前行为的总持续时间、进食时间、进食量和进食次数。l-精氨酸对进食的抑制作用不能归因于运动的变化。这些数据表明，饱腹感部分是通过增加 NO 的产生来介导的。NADPH-黄递酶组织化学染色特异性地用于积极产生 NO 的组织，与饥饿大鼠相比，所有 4 个下丘脑核（室旁核和弓状核、外侧下丘脑和腹内侧下丘脑）中显示出明显更强的染色，这些核均被检查过。l-精氨酸可能通过控制几个下丘脑核中的 NO 产生来作为进食的调节剂，特别是在进食动机较低的情况下。
