与慢性病毒感染相关的自身免疫性肾脏疾病

Autoimmune Kidney Diseases Associated with Chronic Viral Infections.

作者信息

Long Joshua D, Rutledge Stephanie M, Sise Meghan E

机构信息

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, 55 Fruit Street, GRB 7, Boston, MA 02114, USA.

出版信息

Rheum Dis Clin North Am. 2018 Nov;44(4):675-698. doi: 10.1016/j.rdc.2018.06.006. Epub 2018 Sep 7.

DOI:10.1016/j.rdc.2018.06.006

PMID:30274630

Abstract

Autoimmune kidney diseases triggered by viruses are an important cause of kidney disease in patients affected by chronic viral infection. Hepatitis B virus (HBV) infection is associated with membranous nephropathy and polyarteritis nodosa. Hepatitis C virus (HCV) infection is a major cause of cryoglobulinemic glomerulonephritis. Patients with human immunodeficiency virus (HIV) may develop HIV-associated nephropathy, a form of collapsing focal segmental glomerulosclerosis, or various forms of immune-complex-mediated kidney diseases. This article summarizes what is known about the pathogenesis, diagnosis, and management of immune-mediated kidney diseases in adults with chronic HBV, HCV, and HIV infections.

摘要

由病毒引发的自身免疫性肾脏疾病是慢性病毒感染患者肾脏疾病的重要病因。乙型肝炎病毒（HBV）感染与膜性肾病和结节性多动脉炎相关。丙型肝炎病毒（HCV）感染是冷球蛋白血症性肾小球肾炎的主要病因。人类免疫缺陷病毒（HIV）感染者可能会发展为HIV相关性肾病，这是一种塌陷型局灶节段性肾小球硬化症，或各种形式的免疫复合物介导的肾脏疾病。本文总结了关于慢性HBV、HCV和HIV感染的成人免疫介导性肾脏疾病的发病机制、诊断和管理的已知情况。