Rahman Mahmudur G M, Islam Muhammad M, Tsujikawa Tetsuya, Kiyono Yasushi, Okazawa Hidehiko
Biomedical Imaging Research Center, University of Fukui, 23-3, Matsuoka-Shimaizuki, Eiheiji, Fukui, 910-1193, Japan.
Department of Biomedical Engineering, Khulna University of Engineering and Technology, Khulna, Bangladesh.
Ann Nucl Med. 2019 Jan;33(1):14-21. doi: 10.1007/s12149-018-1297-1. Epub 2018 Oct 1.
To calculate the specific binding ratio (SBR) appropriately in dopamine transporter (DAT) imaging, a method for extracting the striatal volume of interest (VOI) was developed.
This study included 200 patients (72 ± 10 years) who were suspected of parkinsonian syndromes (PS) or dementia with Lewy body (DLB). The patients were divided into three groups of PS with dopaminergic degeneration, DLB and non-PS after [I]ioflupane (FP-CIT) SPECT and clinical follow-up. The image data were reconstructed with CT attenuation correction and scatter correction, and with only CT attenuation correction (CTAC). The new method extracted striatal VOI according to the high-level counts and the average striatum volume, and calculated SBR using the reference occipital counts. The SBR values for each patient were obtained using the Tossici-Bolt method (SBR) and our method. Reproducibility of SBR calculation using our method was compared by two operators.
The mean SBR values for the PS and DLB groups were significantly different from that of the non-PS group with both methods. The coefficients of variation of the SBR were significantly smaller with the proposed method compared with those of SBR (p < 0.001), except for the CTAC images. There were no differences in SBR between the two operators using our method. The diagnostic accuracies with our method for the PS and DLB groups were 98.4 and 96.0%, respectively.
Our new method for SBR calculation in the FP-CIT SPECT showed less coefficients of variation with high reproducibility, which would be useful for clinical diagnosis and in assessing the severity of diseases in follow-up studies.
为了在多巴胺转运体（DAT）成像中准确计算特异性结合率（SBR），开发了一种提取纹状体感兴趣区（VOI）的方法。
本研究纳入了200例疑似帕金森综合征（PS）或路易体痴呆（DLB）的患者（72±10岁）。在进行[I]碘氟潘（FP-CIT）单光子发射计算机断层扫描（SPECT）和临床随访后，将患者分为多巴胺能变性的PS组、DLB组和非PS组。图像数据采用CT衰减校正和散射校正以及仅CT衰减校正（CTAC）进行重建。新方法根据高计数和平均纹状体体积提取纹状体VOI，并使用枕叶参考计数计算SBR。使用Tossici-Bolt方法（SBR）和我们的方法获得每位患者的SBR值。由两名操作人员比较使用我们的方法计算SBR的可重复性。
两种方法下，PS组和DLB组的平均SBR值与非PS组均有显著差异。除CTAC图像外，与SBR相比，所提方法的SBR变异系数显著更小（p<0.001）。使用我们的方法，两名操作人员计算的SBR无差异。我们的方法对PS组和DLB组的诊断准确率分别为98.4%和96.0%。
我们在FP-CIT SPECT中计算SBR的新方法变异系数更小，具有高可重复性，这将有助于临床诊断以及在随访研究中评估疾病严重程度。
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