Garrido Pilar, Viñolas Nuria, Isla Dolores, Provencio Mariano, Majem Margarita, Artal Angel, Carcereny Enric, Garcia Campelo Rosario, Lianes Pilar, De La Peñas Ramon, Felip Enriqueta
Hospital Universitario Ramón y Cajal, Madrid, Spain.
Hospital Clínic de Barcelona, Barcelona, Spain.
Eur J Cancer Care (Engl). 2019 Jan;28(1):e12941. doi: 10.1111/ecc.12941. Epub 2018 Oct 2.
The WORLD07 study was a female-specific database, to prospectively characterise the clinical, histological, molecular and treatment-related features in Spanish women with lung cancer. Data were collected from patients' medical records and patient interviews from October 2007 to December 2012. A total of 2,060 women were analysed: median age, 61.3 years; white, 98.6%; postmenopausal, 80.2%; and no smokers, 55% including never smokers and ex-smokers. A family history of cancer was found in 42.5% of patients, 12.0% of patients had had a previous history of cancer (breast cancer, 39.7%). Most patients (85.8%) were diagnosed of non-small-cell lung cancer (NSCLC), most commonly reported with adenocarcinoma (71.4%), which was stage IV at diagnosis in 57.6%. Median overall survival (OS) for the entire population was 24.0 months, with a 1- and 2-year survival rate of 70.7% and 50.0% respectively. Median OS in patients with small-cell lung cancer was 18.8 months versus 25.0 months in patients with NSCLC (p = 0.011). Lung cancer appears to be a biologically different disease in women. By collecting prospective information about characteristics of women with lung cancer attending university hospitals in Spain, we hope to highlight the need to develop strategies based on gender differences and influence future healthcare policy.
WORLD07研究是一个针对女性的数据库，旨在前瞻性地描述西班牙肺癌女性患者的临床、组织学、分子及治疗相关特征。数据收集于2007年10月至2012年12月期间患者的病历及患者访谈。共分析了2060名女性：中位年龄61.3岁；白人占98.6%；绝经后女性占80.2%；不吸烟者占55%（包括从不吸烟者和已戒烟者）。42.5%的患者有癌症家族史，12.0%的患者有既往癌症史（乳腺癌占39.7%）。大多数患者（85.8%）被诊断为非小细胞肺癌（NSCLC），最常见的是腺癌（71.4%），其中57.6%在诊断时为IV期。整个人群的中位总生存期（OS）为24.0个月，1年和2年生存率分别为70.7%和50.0%。小细胞肺癌患者的中位OS为18.8个月，而NSCLC患者为25.0个月（p = 0.011）。肺癌在女性中似乎是一种生物学上不同的疾病。通过收集西班牙大学医院肺癌女性患者特征的前瞻性信息，我们希望强调基于性别差异制定策略的必要性，并影响未来的医疗政策。
