生长分化因子 8、11 与神经性厌食症女孩骨密度的关系。

Relationship between serum level of growth differentiation factors 8, 11 and bone mineral density in girls with anorexia nervosa.

机构信息

Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, China.

Department of Science and Education, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, China.

出版信息

Clin Endocrinol (Oxf). 2019 Jan;90(1):88-93. doi: 10.1111/cen.13871. Epub 2018 Oct 25.

DOI:10.1111/cen.13871

PMID:30281844

Abstract

BACKGROUND

Adolescents with anorexia nervosa (AN) have low body mass and low bone mineral density (BMD). Growth differentiation factor 8 (Myostatin, GDF8) and its homologue growth differentiation factor 11 (GDF11), members of the TGF-β super-family, play an important role in muscle regeneration and bone metabolism in healthy individuals. However, their association with BMD in AN is unknown. The present study was undertaken to investigate the relationship between GDF8, GDF11 and BMD in adolescent girls with AN.

METHODS

Serum GDF8, GDF11 and BMD were determined in 25 girls (12-16 years old) with AN and 31 healthy girls (12-16 years old).

RESULTS

Growth differentiation factor 8 levels were lower in AN subjects. On the contrary, GDF11 levels were higher in AN subjects than controls. There was no relationship between GDF8 and BMD. A significant negative correlation between GDF11 and BMD was found. In multiple linear stepwise regression analysis, BMI, 25-hydroxyvitamin D, GDF11, or lean mass, but not fat mass and GDF8, were independent predictors of BMD in the AN and control groups separately.

CONCLUSIONS

Growth differentiation factor 11 was independent predictor of BMD in girls with AN. It suggested that GDF11 exerts a negative effect on bone mass.

摘要

背景

患有神经性厌食症（AN）的青少年体质量较低，骨矿物质密度（BMD）也较低。生长分化因子 8（肌肉生长抑制素，GDF8）及其同源物生长分化因子 11（GDF11），是转化生长因子-β超家族的成员，在健康个体的肌肉再生和骨代谢中发挥重要作用。然而，它们与 AN 患者 BMD 的关系尚不清楚。本研究旨在探讨 AN 青少年血清 GDF8、GDF11 与 BMD 的关系。