Service de Médecine Nucléaire, Groupe Hospitalier Pitié Salpêtrière-Charles Foix, AP-HP, Paris CEDEX 13, France.
INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, and Université Pierre et Marie Curie-Paris 6, UMR S 1127, Institut du Cerveau et de la Moelle épinière (ICM), FrontLab, Paris CEDEX 13, France.
J Alzheimers Dis. 2018;66(1):271-280. doi: 10.3233/JAD-180087.
Semantic variant of primary progressive aphasia (svPPA) is typically associated with non-Alzheimer's disease (AD) pathology. However, some anatomopathological studies have found AD lesions in those patients. We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant.
语义变异型原发性进行性失语症（svPPA）通常与非阿尔茨海默病（AD）病理学有关。然而，一些解剖病理学研究在这些患者中发现了 AD 病变。我们比较了 18 名 svPPA 患者的脑灌注 SPECT 与脑脊液（CSF）生物标志物，这些标志物表明存在非 AD 病理学（svPPA-nonAD），以及 3 名 svPPA 患者的 CSF 生物标志物表明存在潜在的 AD（svPPA-AD）。所有 svPPA 患者的左侧颞极均存在严重的灌注不足。svPPA-nonAD 还存在前扣带回和中额回灌注不足，而 svPPA-AD 则存在更大的左侧顶叶和后扣带回受累。svPPA 中的顶叶损伤构成了潜在阿尔茨海默病病理学的生物标志物，从而细化了这种 PPA 变体的分类。
