Chicherin I Yu, Pogorelsky I P, Lundovskikh I A, Darmov I V, Shabalina M R, Podvolotsky A N
Eksp Klin Gastroenterol. 2016(7):106-20.
Probiotics for decades were leading in the arsenal of tools for correction of intestinal microbiocenosis. However, the response of representatives of intestinal microbiota to enteral intake of probiotics is variable, and in some individuals may be missing. Despite the fact that scientists still disagree on the necessity of forced settlement of normal microbiota at intestinal dysbiosis, large number of medicinal products, functional foods, dietary supplements, which efficiency is not always straightforward, is available for sale. The results of comparative experimental study of the effectiveness of 18 modern preparations for correction of intestinal microbiocenosis at antibiotic-associated dysbiosis in animals are presented. Conclusion is done on the need to evaluate efficacy and safety of tools developed for intestinal microbiota correction in animal experiments, followed by confirmation of clinical trials.
几十年来，益生菌一直是纠正肠道微生物群落工具库中的主导。然而，肠道微生物群代表对经肠道摄入益生菌的反应是可变的，在某些个体中可能没有反应。尽管科学家们对于在肠道菌群失调时强制植入正常微生物群的必要性仍存在分歧，但市面上有大量功效并非总是一目了然的药品、功能性食品和膳食补充剂可供销售。本文展示了对18种用于纠正动物抗生素相关性菌群失调时肠道微生物群落的现代制剂有效性的比较实验研究结果。得出的结论是，有必要在动物实验中评估为纠正肠道微生物群而开发的工具的有效性和安全性，随后进行临床试验予以证实。
