Lee Jun Hui, Kim Seul Ki, Lee Eun Kyoung, Ahn Moon Bae, Kim Shin Hee, Cho Won Kyoung, Cho Kyoung Soon, Jung Min Ho, Suh Byung Kyu
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ann Pediatr Endocrinol Metab. 2018 Sep;23(3):148-153. doi: 10.6065/apem.2018.23.3.148. Epub 2018 Sep 28.
To analyze the effects of clinical and laboratory factors, including insulinlike growth factor (IGF) levels, on the height velocity of normal prepubertal children.
Ninety-five healthy prepubertal children (33 boys, 62 girls) were enrolled. The mean chronological age was 6.3±1.4 years, with a height standard deviation score (SDS) of -0.88±0.70. IGF-1, IGF binding protein-3 (IGFBP-3), SDS for anthropometric measurements, and changes in SDS for anthropometric measurements were analyzed for 1 year, and their associations with 1-year height velocity were investigated.
The group of children with a 1-year height velocity of ≥6 cm were chronologically younger than the group with a 1-year height velocity of <6 cm (5.9±1.3 years vs. 6.7±1.3 years, P=0.004), with a lesser increase of SDS for body mass index (BMI) over 1 year (-0.18±0.68 vs. 0.13±0.53, P=0.014). There were no differences between the 2 groups in IGF-1 SDS and IGFBP-3 SDS. Multiple linear regression showed that baseline chronological age (r=0.243, P=0.026) and height SDS (r=0.236, P=0.030) were positively associated with IGF-1 SDS. Binomial logistic regression showed that an older chronologic age at referral (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.47-0.99) and an increase of BMI SDS over 1 year (OR, 0.41; 95% CI, 0.18-0.89) were associated with a decreased growth possibility of an above-average height velocity (≥6 cm/yr).
Height velocity of normal prepubertal children is affected by an increase of BMI SDS and chronological age. Prepubertal IGF-1 SDS reflects height SDS at the time of measurement but is not associated with subsequent height velocity.
分析包括胰岛素样生长因子（IGF）水平在内的临床和实验室因素对正常青春期前儿童身高增长速度的影响。
纳入95名健康的青春期前儿童（33名男孩，62名女孩）。平均实足年龄为6.3±1.4岁，身高标准差评分（SDS）为-0.88±0.70。对IGF-1、胰岛素样生长因子结合蛋白-3（IGFBP-3）、人体测量指标的SDS以及人体测量指标SDS在1年内的变化进行分析，并研究它们与1年身高增长速度的相关性。
1年身高增长速度≥6 cm的儿童组实足年龄比1年身高增长速度<6 cm的儿童组小（5.9±1.3岁 vs. 6.7±1.3岁，P=0.004），1年内体重指数（BMI）SDS的增加幅度较小（-0.18±0.68 vs. 0.13±0.53，P=0.014）。两组在IGF-1 SDS和IGFBP-3 SDS方面无差异。多元线性回归显示，基线实足年龄（r=0.243，P=0.026）和身高SDS（r=0.236，P=0.030）与IGF-1 SDS呈正相关。二项逻辑回归显示，转诊时实足年龄较大（比值比[OR]，0.68；95%置信区间[CI]，0.47-0.99）以及1年内BMI SDS增加（OR，0.41；95% CI，0.18-0.89）与身高增长速度高于平均水平（≥6 cm/年）的生长可能性降低有关。
正常青春期前儿童的身高增长速度受BMI SDS增加和实足年龄的影响。青春期前IGF-1 SDS反映测量时的身高SDS，但与随后的身高增长速度无关。
