埃塞俄比亚北部结核病患者的死亡时间及危险因素。
Time to death and risk factors among tuberculosis patients in Northern Ethiopia.
作者信息
Asgedom Solomon Weldegebreal, Tesfaye Daniel, Nirayo Yirga Legesse, Atey Tesfay Mehari
机构信息
School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
出版信息
BMC Res Notes. 2018 Oct 4;11(1):696. doi: 10.1186/s13104-018-3806-7.
OBJECTIVE
The main objective of this study was to assess time to death and associated risk factors among tuberculosis (TB) patients.
RESULTS
A total of 769 TB patients were studied and of those, 87 (11.3%) patients died. All of the deaths occurred within 7 months of anti-tuberculosis therapy. Extra-pulmonary TB (AHR = 17.376, 95% CI; 3.88-77.86, p < 0.001) as compared to pulmonary TB and cotrimoxazole prophylaxis therapy (CPT) (AHR = 0.15, 95% CI; 0.03-0.74, p = 0.02) were found to be the predictors of mortality. We noticed higher rates of mortality. Extra-pulmonary TB patients have high risk and TB-HIV co-infected patients who received CPT have low risk of death. Improving early diagnosis of extra-pulmonary TB and early CPT initiation of TB-HIV co-infected patients could minimize patient's mortality.
目的
本研究的主要目的是评估结核病（TB）患者的死亡时间及相关危险因素。
结果
共研究了769例结核病患者，其中87例（11.3%）死亡。所有死亡均发生在抗结核治疗的7个月内。与肺结核相比，肺外结核（调整后风险比[AHR]=17.376，95%置信区间[CI]：3.88 - 77.86，p<0.001）以及复方新诺明预防性治疗（CPT）（AHR=0.15，95%CI：0.03 - 0.74，p=0.02）被发现是死亡率的预测因素。我们注意到死亡率较高。肺外结核患者风险高，而接受CPT的结核病合并艾滋病病毒（TB-HIV）感染患者死亡风险低。改善肺外结核的早期诊断以及对TB-HIV合并感染患者尽早开始CPT治疗可使患者死亡率降至最低。
Zotero 插件