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[与右心血栓相关的肺栓塞的管理与预后:雅尔加杜·乌德拉奥果大学医院的一项前瞻性研究]

[Management and prognosis of pulmonary embolism associated with right heart thrombi: A prospective study at the University Hospital Yalgado Ouédraogo].

作者信息

Seghda T A A, Yaméogo N V, Millogo G R C, Kagambega L, Kologo J, Boro T, Samadoulougou A, Zabsonré P

机构信息

Service de Cardiologie, Centre Hospitalier Universitaire Yalgado Ouédraogo, 03 BP, 7022 Ouagadougou 03, Burkina Faso.

Service de Cardiologie, Centre Hospitalier Universitaire Yalgado Ouédraogo, 03 BP, 7022 Ouagadougou 03, Burkina Faso.

出版信息

Ann Cardiol Angeiol (Paris). 2019 Apr;68(2):65-70. doi: 10.1016/j.ancard.2018.09.004. Epub 2018 Oct 3.

Abstract

OBJECTIVE

To describe the management and evolution of high risk of death pulmonary embolism associated with right heart thrombi.

MATERIAL AND METHODS

We conducted a prospective cohort survey over a 54 month-period, from March 1st, 2012 to September 30th 2015. Were included all patients with pulmonary embolism and having high or intermediate-high risk of death. Patients were divided into two groups according to whether cardiac Doppler-echography found a thrombus in the right chambers or not (ICT+ vs. ICT-). The survival curves for the patients were obtained using the software STATA.

RESULTS

The prevalence of pulmonary embolism associated with right heart thrombi was 4% in our study. Thrombi were mobile, straight localization in all cases. The ICT+group was characterized by a significantly higher proportion of congestive heart and chronic lung disease. The proportion of patients' thrombolysis was significantly higher in the ICT-group. In the ICT+group, thrombolysis significantly reduced mortality giving a 30-day survival of 80% against 20% among patients receiving only heparin.

CONCLUSION

Pulmonary embolism associated with right heart thrombi including the atrium are not exceptional. These patients are at high risk of early death. Thrombolysis is significantly improving the mortality of pulmonary embolism associated with right-sided heart thrombi.

摘要

目的

描述与右心血栓相关的高死亡风险肺栓塞的管理及演变情况。

材料与方法

我们在2012年3月1日至2015年9月30日的54个月期间进行了一项前瞻性队列研究。纳入所有患有肺栓塞且具有高死亡风险或中高死亡风险的患者。根据心脏多普勒超声检查是否发现右心腔内有血栓,将患者分为两组(ICT+组与ICT-组)。使用STATA软件获得患者的生存曲线。

结果

在我们的研究中,与右心血栓相关的肺栓塞患病率为4%。血栓均为可移动的,且均位于右心。ICT+组的特征是充血性心力衰竭和慢性肺病的比例显著更高。ICT-组患者的溶栓比例显著更高。在ICT+组中,溶栓显著降低了死亡率,接受溶栓治疗的患者30天生存率为80%,而仅接受肝素治疗的患者为20%。

结论

与包括心房在内的右心血栓相关的肺栓塞并不罕见。这些患者有早期死亡的高风险。溶栓显著改善了与右心血栓相关的肺栓塞的死亡率。

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