Raph、约翰·弥尔顿·哈根I、球苷脂、吉尔、Rh相关糖蛋白、FORS、JR、LAN、Vel、CD59及奥古斯丁血型系统中抗原抗体的临床意义

Clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems.

作者信息

Moghaddam Mostafa, Naghi Amir A

机构信息

Head of Immunohematology Reference Laboratory, Department of Immunohematology, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization.

Senior Technologist, Department of Immunohematology, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization.

出版信息

Immunohematology. 2018 Sep;34(3):85-90.

PMID:30295501

Abstract

This article reviews information on the clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems. Antibodies to many of the antigens in these groups are rarely encountered because of the high prevalence of the associated antigens in most populations. For many of these antibodies, the clinical significance-that is, the potential to cause reduced survival of transfused antigen-positive red blood cells or a transfusion reaction (e.g., anti-P, anti-Jra, and anti-Lan), and/or hemolytic disease of the fetus and newborn (e.g., anti-RHAG4 and anti-Vel)-has been documented. For other antibodies, their prevalence is so rare that information on the clinical significance of their antibodies is not available (e.g., anti-FORS1).

摘要

本文综述了拉普、约翰·弥尔顿·哈根I、球苷脂、吉尔、Rh相关糖蛋白、FORS、JR、LAN、Vel、CD59和奥古斯丁血型系统中抗原抗体的临床意义相关信息。由于这些血型系统中许多抗原在大多数人群中具有较高的流行率，因此针对这些抗原的抗体很少见。对于其中许多抗体，其临床意义——即导致输入的抗原阳性红细胞存活期缩短或发生输血反应（如抗P、抗Jra和抗Lan），和/或胎儿及新生儿溶血病（如抗RHAG4和抗Vel）的可能性——已有文献记载。对于其他抗体，其发生率极为罕见，因此关于其抗体临床意义的信息尚不可得（如抗FORS1）。