博茨瓦纳和南非无 HIV 感染婴儿中 HIV 暴露相关人群死亡率：基于模型的评估。
Population-level Mortality Associated with HIV Exposure in HIV-uninfected Infants in Botswana and South Africa: A Model-based Evaluation.
机构信息
Doctor, Department of Paediatrics and Child Health Faculty of Medicine and Health Sciences, Stellenbosch University, Worcester, South Africa.
Doctor, Ukwanda Centre for Rural Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Worcester, South Africa.
出版信息
J Trop Pediatr. 2019 Aug 1;65(4):373-379. doi: 10.1093/tropej/fmy064.
We aimed to quantify the contribution of excess mortality in HIV-exposed uninfected (HEU) infants to total mortality in HIV-uninfected infants in Botswana and South Africa in 2013. Population attributable fractions (PAFs) and excess infant deaths associated with HIV exposure in HIV-uninfected infants were estimated. Additionally, the Thembisa South African demographic model estimated the proportion of all infant mortality associated with excess mortality in HEU infants from 1990 to 2013. The PAF (lower bound; upper bound) of mortality associated with HIV exposure in HIV-uninfected infants was 16.8% (2.5; 31.2) in Botswana and 15.1% (2.2; 28.2) in South Africa. Excess infant deaths (lower bound; upper bound) associated with HIV exposure in 2013 were estimated to be 5.6 (0.5; 16.6)/1000 and 4.9 (0.6; 11.2)/1000 HIV-uninfected infants in Botswana and South Africa, respectively. In South Africa, the proportion of all infant (HIV-infected and HIV-uninfected) mortality associated with excess HEU infant mortality increased from 0.4% in 1990 to 13.8% in 2013.
我们旨在量化 2013 年在博茨瓦纳和南非，艾滋病毒暴露未感染（HEU）婴儿的超额死亡率对未感染艾滋病毒婴儿总死亡率的贡献。估计了人口归因分数（PAF）和与未感染艾滋病毒婴儿的艾滋病毒暴露相关的超额婴儿死亡。此外，Thembisa 南非人口动态模型估计了 1990 年至 2013 年与 HEU 婴儿超额死亡率相关的所有婴儿死亡率的比例。与未感染艾滋病毒婴儿的艾滋病毒暴露相关的死亡率的 PAF（下限；上限）在博茨瓦纳为 16.8%（2.5；31.2），在南非为 15.1%（2.2；28.2）。估计 2013 年与艾滋病毒暴露相关的超额婴儿死亡（下限；上限）分别为博茨瓦纳和南非每 1000 名未感染艾滋病毒婴儿 5.6（0.5；16.6）和 4.9（0.6；11.2）。在南非，与所有婴儿（感染艾滋病毒和未感染艾滋病毒）死亡相关的与 HEU 婴儿死亡过多相关的比例从 1990 年的 0.4%增加到 2013 年的 13.8%。
Zotero 插件