异丙肾上腺素对胎兔心肌机械功能和环磷酸腺苷含量的影响。

Effect of isoproterenol on myocardial mechanical function and cyclic AMP content in the fetal rabbit.

作者信息

Okuda H, Nakanishi T, Nakazawa M, Takao A

出版信息

J Mol Cell Cardiol. 1987 Feb;19(2):151-7. doi: 10.1016/s0022-2828(87)80557-6.

Abstract

The effect of isoproterenol on mechanical function was studied in the isolated arterially perfused heart of the fetal (21st and 28th day of gestation) and newborn rabbits. The inotropic effect of isoproterenol in the fetus was less than in the newborn. In contrast, myocardial cyclic AMP levels after isoproterenol infusion in the fetus were greater than in the newborn. The inotropic effects of dibutyryl cyclic AMP and of calcium in the fetus were less than in the newborn. These data suggest that the process from beta-receptor to cyclic AMP in the fetus was equally or even more responsive to isoproterenol than in the newborn. The diminished inotropic effect of isoproterenol in the fetus may be due, at least in part, to the decreased inotropic effect of calcium.

摘要

在胎儿（妊娠第21天和第28天）及新生兔的离体动脉灌注心脏中研究了异丙肾上腺素对机械功能的影响。异丙肾上腺素对胎儿的变力作用小于对新生兔的作用。相反，给胎儿输注异丙肾上腺素后心肌环磷酸腺苷（cAMP）水平高于新生兔。二丁酰环磷酸腺苷和钙对胎儿的变力作用小于对新生兔的作用。这些数据表明，胎儿中从β受体到环磷酸腺苷的过程对异丙肾上腺素的反应与新生兔相同甚至更强。异丙肾上腺素对胎儿变力作用减弱可能至少部分归因于钙的变力作用降低。