Tabeeva G R
Sechenov First Moscow State Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(9):111-116. doi: 10.17116/jnevro2018118091111.
Alzheimer's disease and vascular dementia are two most common causes of dementia in late life. The combination of Alzheimer's type dementia and vascular dementia is the third most common form of dementia, especially in the elderly. Most clinical forms of dementia are characterized by the presence of 'overlap' symptoms of both neurodegenerative and vascular pathology, which makes it expedient to consider mixed dementia as a separate entity characterized by clinical presentations, course and the rate of progression of cognitive decline. Despite the lack of clinical guidelines for management of patients with mixed dementia, it seems appropriate to use strategies that have shown their effectiveness in various types of cognitive impairment.
阿尔茨海默病和血管性痴呆是老年期痴呆最常见的两种病因。阿尔茨海默型痴呆与血管性痴呆的合并症是痴呆的第三种最常见形式，在老年人中尤为如此。大多数临床痴呆形式的特征是同时存在神经退行性病变和血管病变的“重叠”症状，这使得将混合性痴呆视为一个以临床表现、病程和认知衰退进展速度为特征的独立实体是很合适的。尽管缺乏针对混合性痴呆患者管理的临床指南，但采用已在各种类型认知障碍中显示出有效性的策略似乎是恰当的。
