炎症性肠病：极早发型疾病教给我们的知识。
Inflammatory Bowel Disease: What Very Early Onset Disease Teaches Us.
机构信息
Cell Biology Program, Division of Gastroenterology, Hepatology and Nutrition, Inflammatory Bowel Disease Center, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; School of Medicine, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland; Department of Pediatric Gastroenterology, Hepatology and Nutrition, SickKids, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Department of Biochemistry, Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Pediatrics, Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Gastroenterology, Hepatology and Nutrition, Cell Biology Program, Research Institute, The Hospital for Sick Children, University of Toronto, SickKids, Inflammatory Bowel Disease Centre, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
出版信息
Gastroenterol Clin North Am. 2018 Dec;47(4):755-772. doi: 10.1016/j.gtc.2018.07.004. Epub 2018 Oct 4.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, of which ulcerative colitis and Crohn's disease are the 2 most prevailing entities. Very early onset IBD (VEO-IBD) children diagnosed with IBD under age 6 years. Although the etiology of IBD is mostly unknown, it involves a complex interaction among host genetics, microbiota, environmental factors, and aberrant immune responses. Advances in the understanding of the genetic contribution, which appears to be much more significant in younger children, gives us a useful insight into the pathogenesis and potential future therapeutic targets in IBD.
炎症性肠病（IBD）是一种胃肠道的慢性炎症性疾病，其中溃疡性结肠炎和克罗恩病是最常见的两种疾病。非常早发型炎症性肠病（VEO-IBD）是指在 6 岁以下被诊断为 IBD 的儿童。尽管 IBD 的病因大多未知，但它涉及宿主遗传学、微生物群、环境因素和异常免疫反应之间的复杂相互作用。对遗传贡献的理解的进步，在年龄较小的儿童中似乎更为显著，这使我们对 IBD 的发病机制和潜在的未来治疗靶点有了有用的了解。
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