Simbolon Fransiska Romana, Lee Su-Shin, Tsai Yi-Chun, Tsai Wen-Chan, Lin Gau-Tyan, Tung Yi-Ching, Tu Hung-Pin
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Int J Rheum Dis. 2018 Nov;21(11):1993-2001. doi: 10.1111/1756-185X.13393. Epub 2018 Oct 18.
Gout is a common complication in kidney transplant recipients. This study evaluated the association between kidney transplant recipients and the long-term risk of incident gout.
For this age-matched and sex-matched retrospective cohort study, the Catastrophic Illness Certificate Database and the National Health Insurance Research Database were combined between 1997 and 2010. The study included 5917 patients with kidney transplants and 23 668 matched kidney transplant-free subjects. Hazard ratio (HR) for risk of incident gout was calculated using the Cox proportional hazards regression.
In this study, of the 5917 kidney transplant recipients, 521 (8.8%) had gout. The kidney transplant group had a higher risk of incident gout than those in the matched kidney transplant-free group (adjusted HR = 1.55, 95% confidence intervals [CI] = 1.36-1.77), particularly within 3 years following kidney transplant recipients (adjusted HR = 2.61, 95% CI = 2.13-3.20). We observed that at the >3 to 6 years and the >6 to 9 years follow-up, patients with kidney transplant did not have a significant association with risk of incident gout (adjusted HR = 0.92, P = 0.4806 and adjusted HR = 1.26, P = 0.1901, respectively).
These findings revealed that risk of incident gout increased within 3 years following kidney transplant recipients and the individual's long-term risk of incident gout between kidney transplant recipients and the general population remained similar.
痛风是肾移植受者常见的并发症。本研究评估了肾移植受者与痛风发病长期风险之间的关联。
对于这项年龄和性别匹配的回顾性队列研究，1997年至2010年间将重大伤病证明数据库和国民健康保险研究数据库进行了合并。该研究纳入了5917例肾移植患者和23668例匹配的未接受肾移植受试者。使用Cox比例风险回归计算痛风发病风险的风险比（HR）。
在本研究中，5917例肾移植受者中有521例（8.8%）患有痛风。肾移植组痛风发病风险高于匹配的未接受肾移植组（调整后HR = 1.55，95%置信区间[CI] = 1.36 - 1.77），特别是在肾移植受者后的3年内（调整后HR = 2.61，95% CI = 2.13 - 3.20）。我们观察到，在>3至6年和>6至9年的随访中，肾移植患者与痛风发病风险没有显著关联（调整后HR = 0.92，P = 0.4806；调整后HR = 1.26，P = 0.1901）。
这些发现表明，肾移植受者后3年内痛风发病风险增加，肾移植受者与普通人群之间痛风发病的个体长期风险相似。
