Agriculture College, Guangdong Ocean University, Zhanjiang, Guangdong Province, China.
College of Wildlife Resources, Northeast Forestry University, Harbin, Heilongjiang Province, China.
Transbound Emerg Dis. 2019 May;66(3):1142-1157. doi: 10.1111/tbed.13044. Epub 2019 Mar 3.
Human infectious avian influenza virus (AIV) H7N9 emerged in China in 2013. The N9 gene of H7N9, which has the ability to cause death in humans, originated from an H11N9 influenza strain circulating in wild birds. To investigate the frequency and distribution of the N9 gene of the H11N9 and H7N9 influenza virus circulating in wild birds between 2006 and 2015, 35,604 samples were collected and tested. No H7N9 but four strains of the H11N9 subtype AIV were isolated, and phylogenetic analyses showed that the four H11N9 viruses were intra-subtype and inter-subtype reassortant viruses. A sequence analysis revealed that all six internal genes of A/wild bird/Anhui/L306/2014 (H11N9) originated from an H9N2 AIV isolated in Korea. The H9N2 strain, which is an inner gene donor reassorted with other subtypes, is a potential threat to poultry and even humans. It is necessary to increase monitoring of the emergence and spread of H11N9 AIV in wild birds.
人感染禽流感病毒（AIV）H7N9 于 2013 年在中国出现。具有致人死亡能力的 H7N9 的 N9 基因源自于在野生鸟类中流行的 H11N9 流感株。为了研究 2006 年至 2015 年间在野生鸟类中流行的 H11N9 和 H7N9 流感病毒 N9 基因的频率和分布，共采集并检测了 35604 个样本。未分离到 H7N9，但分离到了 4 株 H11N9 亚型 AIV，系统进化分析表明，这 4 株 H11N9 病毒均为同型内和异型间重配病毒。序列分析显示，A/wild bird/Anhui/L306/2014（H11N9）的所有 6 个内部基因均源自韩国分离到的一株 H9N2 AIV。H9N2 株是与其他亚型重配的内基因供体，对家禽乃至人类构成潜在威胁。有必要加强对野生鸟类中 H11N9 AIV 的出现和传播的监测。
