Boll Griffin, Fischer Ariel, Kapur Navin K, Salehi Payam
Department of Surgery, Tufts Medical Center, Boston, MA.
Department of Cardiology, Tufts Medical Center, Boston, MA.
Ann Vasc Surg. 2019 Jan;54:54-59. doi: 10.1016/j.avsg.2018.10.004. Epub 2018 Oct 17.
Impella 5.0 is a powerful mechanical circulatory support device placed into the left ventricle of patients in cardiogenic shock not responding to pharmacologic support alone. This therapy can support patient hemodynamics from weeks to several months, and patients can potentially ambulate with the device implanted while awaiting destination therapy.
From July 2012 to September 2017, 22 Impella 5.0 devices (Abiomed Inc., Danvers, MA) were implanted via right axillary artery at our center. All devices were implanted under fluoroscopic and transesophageal echocardiographic guidance.
Eighty-one percent of patients were male, and average age was 61 years (range 27-73). A 10- or 12-mm graft was used in 96% of the cases, most commonly Hemashield (Maquet, Rastatt, Germany; 46%) or Dacron (DuPont, Wilmington, DE; 23%). The graft was tunneled laterally in a subcutaneous plane in 91% of the cases. All attempts at right axillary artery conduit creation and device implantation were successful. The angle of end-to-side anastomosis was 45-60°. The average duration of therapy was 8.8 days (range 1-19). There were no brachial plexus injuries, patients with upper extremity ischemia, or bleeding requiring intervention in the postoperative period. One patient was coagulopathic and developed a hemorrhagic stroke. Concurrent use of mechanical circulatory support for the right heart was present in 27% of the cases. Twenty-seven percent of patients bridged successfully to ventricular assist devices, 18% recovered to have the device explanted, and 55% of patients died within 30 days of device implantation.
Right axillary artery conduit is a safe and reliable access for implantation of Impella 5.0. This technique appears to be associated with low complication rates when implanted with a standardized technique.
Impella 5.0是一种强大的机械循环支持设备,用于对单纯药物治疗无反应的心源性休克患者的左心室。这种治疗可在数周至数月内支持患者的血流动力学,患者在植入该设备等待最终治疗期间有可能带着设备活动。
2012年7月至2017年9月,我们中心通过右腋动脉植入了22台Impella 5.0设备(美国马萨诸塞州丹弗斯市的Abiomed公司)。所有设备均在荧光透视和经食管超声心动图引导下植入。
81%的患者为男性,平均年龄61岁(范围27 - 73岁)。96%的病例使用了10或12毫米的移植物,最常用的是Hemashield(德国拉施塔特的迈柯唯公司;46%)或涤纶(美国特拉华州威尔明顿的杜邦公司;23%)。91%的病例中移植物在皮下平面横向隧道化。所有右腋动脉导管建立和设备植入尝试均成功。端侧吻合角度为45 - 60°。平均治疗持续时间为8.8天(范围1 - 19天)。术后期间无臂丛神经损伤、上肢缺血患者或需要干预的出血情况。1例患者出现凝血功能障碍并发生出血性卒中。27%的病例同时使用了右心机械循环支持。27%的患者成功过渡到心室辅助装置,18%恢复后取出了设备,55%的患者在设备植入后30天内死亡。
右腋动脉导管是植入Impella 5.0的安全可靠入路。采用标准化技术植入时,该技术似乎并发症发生率较低。