123例神经肌肉疾病患者肌肉活检和肌电图的诊断准确性
Diagnostic Accuracy of Muscle Biopsy and Electromyography in 123 Patients with Neuromuscular Disorders.
作者信息
Constantinides Vasilios C, Papahatzaki Maria Martha, Papadimas Georgios K, Karandreas Nikos, Zambelis Thomas, Kokotis Panagiotis, Manda Panagiota
机构信息
First Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece
First Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece.
出版信息
In Vivo. 2018 Nov-Dec;32(6):1647-1652. doi: 10.21873/invivo.11427.
BACKGROUND/AIM: Diagnostic accuracy of muscle biopsy and electromyography (EMG) in patients with myopathy varies widely among studies. The goal of this study was to examine the diagnostic accuracy of each method in the diagnosis of patients with suspected myopathy, and determine the level of agreement between the two methods.
PATIENTS AND METHODS
The files of all patients with a presumed myopathy were retrospectively reviewed. All patients with detailed muscle biopsy and EMG data were included.
RESULTS
A total of 123 patients were included. Accuracy of biopsy was 80.4% compared to 70.7% for EMG. Biopsy was sensitive and specific in all neuromuscular disorders. EMG was accurate in neurogenic disorders. Biopsy and EMG agreement was 70.7%.
CONCLUSION
Muscle biopsy is more accurate than EMG in patients with myopathy. Muscle biopsy-EMG discordance can be attributed to different muscle sampling and to disorders with both neurogenic and myopathic features, such as acquired and mitochondrial myopathies.
背景/目的：关于肌病患者肌肉活检和肌电图（EMG）的诊断准确性，各研究间差异很大。本研究的目的是检验每种方法在疑似肌病患者诊断中的准确性，并确定两种方法之间的一致性水平。
患者与方法
对所有疑似肌病患者的病历进行回顾性审查。纳入所有有详细肌肉活检和肌电图数据的患者。
结果
共纳入123例患者。活检的准确率为80.4%，而肌电图为70.7%。活检在所有神经肌肉疾病中均具有敏感性和特异性。肌电图在神经源性疾病中诊断准确。活检与肌电图的一致性为70.7%。
结论
在肌病患者中，肌肉活检比肌电图更准确。肌肉活检与肌电图结果不一致可能归因于不同的肌肉采样，以及具有神经源性和肌病特征的疾病，如获得性和线粒体肌病。
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