Zhang He, Hong Tian Yu, Li Gang, Jiang Ning, Hu Chuanyi, Cui Xingang, Chu Chuanmin, Zhao Jun Long
Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Urology, Shanghai Pudong New Area Gongli Hospital, Shangha, China.
Urol Int. 2019;102(2):153-159. doi: 10.1159/000493508. Epub 2018 Oct 23.
To compare the efficacy of new percutaneous technique ("ultra-mini PCNL", UMP), shock wave lithotripsy (SWL) and flexible ureteroscopy (FURS) on the treatment of 1-2 cm lower pole kidney stones, and to determine the advantages and disadvantages of each method.
This prospective study was based on data collected from the files of patients between March 2015 and March 2017. This study recruited a total of 180 patients with single radio-opaque lower caliceal calculi of 1-2 cm. All patients were randomly divided into 3 groups: group A was treated with UMP, group B was treated with FURS by using holmium laser and group C was treated with SWL by using the electromagnetic lithotripter. The average age, sex, size of the stone, the time of operation, the rate of no stone, the time of hospitalization, the rate of retreatment, the cost and the complications of the 3 groups were compared. The success of the operation was defined as no residual stone or < 0.3 cm on computed tomography at 3 months postoperatively.
The stone burdens of the groups were equivalent. The re-treatment rate in group C was significantly higher than that in group A and B (30 vs. 1.6%, 5%). The average operating time in group B (93.35 ± 21.64 min) was statistically significantly longer than that in group A and C (68.58 ± 15.82 min, 46.33 ± 5.81 min). Although the time of hospitalization of group A (5.32 ± 1.20 day) was longer than that of group B (3.22 ± 0.52 day) and C (1.08 ± 0.28 day; p < 0.05). The stone-free rate (SFR) in UMP, FURS, SWL were 98, 92, and 73% respectively; the highest SFR was in the UMP group (p < 0.05). The complication rates were evaluated by using the Clavien grading system, which were determined to be 16.67% in UMP, 6.67% in SWL and 8.33% in FURS. In particular, the complications of GI and GII were more common in group A (p < 0.05).
UMP, FURS, and SWL are all safe and effective in the treatment of 1-2 cm lower pole kidney stones. UMP and FURS had a better SFR than SWL, but the time of hospitalization in UMP group was longer and there were more complications in the UMP group. In addition, the operation time of FURS is longer as compared to UMP and SWL, and there is a higher rate of postoperative fever. The invasiveness and cost of SWL were lower than that of UMP and FURS, but the re-treatment rate was higher.
比较新型经皮技术(“超微通道经皮肾镜取石术”,UMP)、冲击波碎石术(SWL)及软性输尿管镜检查术(FURS)治疗1-2cm下极肾结石的疗效,并确定每种方法的优缺点。
本前瞻性研究基于2015年3月至2017年3月期间患者病历收集的数据。本研究共纳入180例单发性不透X线的1-2cm下盏结石患者。所有患者随机分为3组:A组采用UMP治疗,B组采用钬激光软性输尿管镜检查术治疗,C组采用电磁式碎石机进行SWL治疗。比较3组患者的平均年龄、性别、结石大小、手术时间、无石率、住院时间、再次治疗率、费用及并发症情况。手术成功定义为术后3个月计算机断层扫描无残留结石或残留结石<0.3cm。
3组患者的结石负荷相当。C组的再次治疗率显著高于A组和B组(30%对1.6%、5%)。B组的平均手术时间(93.35±21.64分钟)在统计学上显著长于A组和C组(68.58±15.82分钟、46.33±5.81分钟)。尽管A组的住院时间(5.32±1.20天)长于B组(3.22±0.52天)和C组(1.08±0.28天;p<0.05)。UMP、FURS、SWL的无石率分别为98%、92%和73%;UMP组的无石率最高(p<0.05)。采用Clavien分级系统评估并发症发生率,UMP组为16.67%,SWL组为6.67%,FURS组为8.33%。特别是A组的胃肠道及二级并发症更为常见(p<0.05)。
UMP、FURS和SWL治疗1-2cm下极肾结石均安全有效。UMP和FURS的无石率优于SWL,但UMP组的住院时间更长且并发症更多。此外,与UMP和SWL相比,FURS的手术时间更长,术后发热率更高。SWL的侵入性和费用低于UMP和FURS,但再次治疗率更高。