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大处着眼小腺瘤:向“精准监测”迈进。

Thinking Big About Small Adenomas: Moving Toward "Precision Surveillance".

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Center for Innovation, Health Services Research and Development, The Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. Regenstrief Institute, Inc, Indianapolis, IN, USA.

出版信息

Am J Gastroenterol. 2018 Dec;113(12):1760-1762. doi: 10.1038/s41395-018-0397-9. Epub 2018 Oct 23.

DOI:10.1038/s41395-018-0397-9
PMID:30353059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6768625/
Abstract

Quality metrics and technological advances for colonoscopy are contributing to detection of more diminutive and small adenomas, increasing the proportion of persons undergoing surveillance for non-advanced neoplasia. In this issue, Kim and colleagues report surveillance colonoscopy findings in average-risk Koreans who had one or more adenomas on a first screening colonoscopy and found a similar risk of metachronous advanced neoplasia between those with 1-2 non-advanced adenoma (the "low-risk adenoma" group) and those with 3 or more small adenomas. The validity, generalizability, and clinical implications of the findings are considered along with recent similar studies. In sum, these studies support expanding the low-risk subgroup to include up to four diminutive tubular adenomas and perhaps persons with up to four small tubular adenomas. They also prompt consideration of "precision surveillance" that considers features of not just the polyps, but of the patient and endoscopist.

摘要

结肠镜检查的质量指标和技术进步有助于检测更小和更小的腺瘤,增加了接受非进展性肿瘤监测的人群比例。在本期中,Kim 及其同事报告了在首次筛查结肠镜检查中发现一个或多个腺瘤的韩国普通风险人群的监测结肠镜检查结果,发现具有 1-2 个非进展性腺瘤(“低危腺瘤”组)和具有 3 个或更多小腺瘤的人群之间存在相似的异时性高级别肿瘤风险。考虑到最近的类似研究,对这些发现的有效性、可推广性和临床意义进行了考虑。总之,这些研究支持将低危亚组扩大到包括多达四个微小管状腺瘤,甚至可能包括多达四个小的管状腺瘤的患者。它们还促使人们考虑“精准监测”,不仅考虑息肉的特征,还考虑患者和内镜医生的特征。

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Presence of small sessile serrated polyps increases rate of advanced neoplasia upon surveillance compared with isolated low-risk tubular adenomas.与孤立的低风险管状腺瘤相比,存在小的无蒂锯齿状息肉会增加监测时进展期肿瘤的发生率。
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引用本文的文献

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Gastrointest Endosc. 2019 Sep;90(3):495-501. doi: 10.1016/j.gie.2019.05.029. Epub 2019 May 22.

本文引用的文献

1
Risk of Metachronous Advanced Neoplasia in Patients With Multiple Diminutive Adenomas.多发性微小腺瘤患者的异时性高级别肿瘤风险。
Am J Gastroenterol. 2018 Dec;113(12):1855-1861. doi: 10.1038/s41395-018-0210-9. Epub 2018 Aug 3.
2
Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence.结肠镜检查腺瘤发现与长期结直肠癌发病率的关系。
JAMA. 2018 May 15;319(19):2021-2031. doi: 10.1001/jama.2018.5809.
3
The effect of small or diminutive adenomas at baseline colonoscopy on the risk of developing metachronous advanced colorectal neoplasia: KASID multicenter study.基线结肠镜检查中小或微小腺瘤对发生结肠直肠腺瘤性息肉进展的风险的影响:KASID 多中心研究。
Dig Liver Dis. 2018 Aug;50(8):847-852. doi: 10.1016/j.dld.2018.04.001. Epub 2018 Apr 11.
4
Risk of Advanced Adenoma, Colorectal Cancer, and Colorectal Cancer Mortality in People With Low-Risk Adenomas at Baseline Colonoscopy: A Systematic Review and Meta-Analysis.基线结肠镜检查时低风险腺瘤患者发生晚期腺瘤、结直肠癌及结直肠癌死亡的风险:一项系统评价与Meta分析
Am J Gastroenterol. 2017 Dec;112(12):1790-1801. doi: 10.1038/ajg.2017.360. Epub 2017 Oct 31.
5
Adenoma detection rate influences the risk of metachronous advanced colorectal neoplasia in low-risk patients.腺瘤检出率影响低危患者结直肠腺瘤间期高级别肿瘤的风险。
Gastrointest Endosc. 2018 Mar;87(3):809-817.e1. doi: 10.1016/j.gie.2017.09.028. Epub 2017 Oct 4.
6
Risk of advanced colorectal neoplasm by the proposed combined United States and United Kingdom risk stratification guidelines.按美国和英国联合提出的风险分层指南评估结直肠进展性腺瘤的风险。
Gastrointest Endosc. 2018 Mar;87(3):800-808. doi: 10.1016/j.gie.2017.09.023. Epub 2017 Oct 3.
7
Risk of advanced lesions at the first follow-up colonoscopy after polypectomy of diminutive versus small adenomatous polyps of low-grade dysplasia.低级别异型增生的微小和小腺瘤性息肉切除后首次随访结肠镜检查时高级别病变的风险。
Gastrointest Endosc. 2017 Oct;86(4):713-721.e2. doi: 10.1016/j.gie.2017.02.034. Epub 2017 Mar 8.
8
Evaluating a Modular Decision Support Application For Colorectal Cancer Screening.评估用于结直肠癌筛查的模块化决策支持应用程序。
Appl Clin Inform. 2017 Feb 15;8(1):162-179. doi: 10.4338/ACI-2016-09-RA-0152.
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Rationale and design of the European Polyp Surveillance (EPoS) trials.欧洲息肉监测(EPoS)试验的原理与设计
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Risk of advanced lesions at first follow-up colonoscopy in high-risk groups as defined by the United Kingdom post-polypectomy surveillance guideline: data from a single U.S. center.英国息肉切除术后监测指南定义的高危人群在首次随访结肠镜检查时出现高级别病变的风险:来自美国单中心的数据。
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