应用人类遗传流行病学。

Applied Human Genetic Epidemiology.

机构信息

Epidemiology and Biostatistics, Loma Linda University School of Medicine and Public Health, Sunnyvale, CA, USA.

出版信息

Adv Exp Med Biol. 2018;1082:145-216. doi: 10.1007/978-3-319-93791-5_4.

Abstract

This chapter covers the study of human epidemiology, including family studies in genetic epidemiology, linkage analysis, genetic Mapping in human diseases, human genetic influences on diseases, genetic relationships in familial aggregation, and derivation of familial risk.An Illustration is provided of a research project in genetic epidemiology research which included (1) Heritability Analysis (2) Molecular Variation Study Methods (3) Genomics for Human Genetic Epidemiology Complex Traits and Mendelian Inheritance Mendel's Laws Hardy-Weinberg Principle Gene Structure and Genetic Code Genetic Linkage and Linkage Disequilibrium Study Designs for of Rare Genetic Variations Spectrum of Variation Familial Factors in Human Genetic Epidemiology *Human Genetic Association Genetic Epidemiology Owing to Population Stratification Environmental Effects on Genetic Epidemiology Genetic Epidemiology and Public Health.

摘要

这一章涵盖了人类流行病学的研究，包括遗传流行病学中的家系研究、连锁分析、人类疾病中的遗传图谱、疾病的遗传影响、家族聚集中的遗传关系以及家族风险的推导。本文提供了一个遗传流行病学研究项目的实例，其中包括（1）遗传力分析、（2）分子变异研究方法、（3）人类遗传流行病学复杂特征和孟德尔遗传的基因组学、孟德尔定律、哈迪-温伯格原理、基因结构和遗传密码、遗传连锁和连锁不平衡、罕见遗传变异的研究设计、变异谱、人类遗传流行病学中的家族因素、人类遗传关联、遗传流行病学、由于人口分层、遗传流行病学中的环境效应和遗传流行病学与公共卫生。