CORRELATION OF RED BLOOD FACTORS IN POLYTRAUMA INDUCED SEPSIS AND SEPTIC SHOCK PATIENTS.

In polytrauma induced sepsis/septic shock patients, early verification and diagnosing anemia, is an important factor for the outcome of pathology. The purpose of our study was: to study the dynamic correlation of the red blood markers and inflammatory indicators. We consider that knowing these mechanisms will be helpful in the management/treatment method selection and in making prognosis of the final outcomes of polytrauma induced sepsis /septic shock patients. The purpose of our study was to study the characteristic dynamic correlations of polytrauma induced red blood and inflammation indicators. The abovementioned information will play an important and crucial role in the management of hypoxemic changes in different types of anemia. The red blood markers and inflammatory indicators dynamic correlations were studied in 21 Polytrauma induced Septic Shock patients during the first 45 days after hospital admission. Pearson Scheme was used for data analysis. All the patients were adults and were treated by the International Guidelines for Management of Severe Sepsis and Septic Shock, considering the bacterial spectrum. In the initial period of polytrauma injury, the deficit of red blood markers was a result of trauma induced hemorrhage and sequential surgical interventions. The dynamic reduce in red blood markers were in negative correlation with the elevation of systematic inflammatory factors, indicating polytrauma induced septic complication. In the period of reconvalescence, the concentration of red blood markers was normalizing, in negative correlation with the specific inflammatory factors. Our study revealed, that non-specific inflammatory marker, like fibrinogen is in strong correlation with the tissue oxygenation. Also the study demonstrated the correlation of Oxymetric parameters with the inflammatory factor metabolites. In particular, the elevation of fibrinogen concentration is in positive correlation with the tissue oxygenation quality.