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剖宫产时行产后输卵管结扎术或作为间隔绝育术通过腹腔镜进行输卵管结扎术,对卵巢储备功能的影响相似。

Post-partum tubal ligation at time of cesarean delivery or via laparoscopy as an interval sterilization has similar effects on ovarian reserve.

作者信息

Gemici Ali, Şükür Yavuz Emre, Tülek Fırat, Taşkın Salih, Atabekoğlu Cem Somer

机构信息

Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey

出版信息

J Turk Ger Gynecol Assoc. 2020 Mar 6;21(1):24-28. doi: 10.4274/jtgga.galenos.2018.2018.0087. Epub 2018 Oct 26.

Abstract

OBJECTIVE

To observe and compare the effect of postpartum tubal ligation (TL) procedures on ovarian reserve at women desiring TL as a contraceptive method at the end of pregnancy.

MATERIAL AND METHODS

Eighty-one women were included in the prospective study. TL was performed at the time of cesarean delivery (CD) (n=49) and as an interval procedure by laparoscopy (LS) in the postpartum period (n=32). Anti-müllerian hormone (AMH) was used to determine ovarian reserve. Blood samples were taken twice from each subject; the first sample was taken before delivery from all subjects and the second sample was taken 4 months after sterilization. AMH level differences were compared in each group and between groups.

RESULTS

The preoperative AMH values of CD and LS groups were similar 2.30 (maximum: 5.20, minimum: 0.42) ng/mL and 1.80 (maximum: 3.50, minimum: 0.40) ng/mL, respectively (p=0.262). The postoperative AMH values of the CD and LS groups were 1.30 (maximum: 2.60, minimum: 0.30) ng/mL and 0.90 (maximum: 2.50, minimum: 0.20) ng/mL, respectively (p=0.284). When the preoperative and postoperative values of each group were compared the change was statistically significant for both groups p<0.001. The decrease in mean AMH values in the CD and LS groups were 37.83% and 44.15%, respectively. The percentage changes of AMH values were not statistically significant (p=0.286).

CONCLUSION

TL at the time of CD and interval sterilization with LS have similar effects on ovarian reserve.

摘要

目的

观察并比较产后输卵管结扎(TL)手术对妊娠末期希望采用TL作为避孕方法的女性卵巢储备功能的影响。

材料与方法

81名女性纳入前瞻性研究。剖宫产(CD)时进行TL(n = 49),产后期间通过腹腔镜检查(LS)作为间隔手术进行TL(n = 32)。使用抗苗勒管激素(AMH)来确定卵巢储备功能。从每个受试者采集两次血样;所有受试者在分娩前采集第一份样本,绝育后4个月采集第二份样本。比较每组以及组间的AMH水平差异。

结果

CD组和LS组术前AMH值相似,分别为2.30(最大值:5.20,最小值:0.42)ng/mL和1.80(最大值:3.50,最小值:0.40)ng/mL(p = 0.262)。CD组和LS组术后AMH值分别为1.30(最大值:2.60,最小值:0.30)ng/mL和0.90(最大值:2.50,最小值:0.20)ng/mL(p = 0.284)。比较每组术前和术后的值,两组的变化均具有统计学意义(p<0.001)。CD组和LS组平均AMH值的下降分别为37.83%和44.15%。AMH值的百分比变化无统计学意义(p = 0.286)。

结论

剖宫产时进行TL和通过LS进行间隔绝育对卵巢储备功能的影响相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6cd/7075397/d3a689ab6ccb/JTGGA-21-24-g1.jpg

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