Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Cell Physiol. 2019 Apr;234(4):3394-3409. doi: 10.1002/jcp.27326. Epub 2018 Oct 26.
Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into different cell types. Owing to their immunosuppressive and anti-inflammatory properties, they are widely used in regenerative medicine, but they have a dual effect on cancer progression and exert both growth-stimulatory or -inhibitory effects on different cancer types. It has been proposed that these controversial effects of MSC in tumor microenvironment (TME) are mediated by their polarization to proinflammatory or anti-inflammatory phenotype. In addition, they can polarize the immune system cells that in turn influence tumor progression. One of the mechanisms involved in the TME communications is extracellular vesicles (EVs). MSCs, as one of cell populations in TME, produce a large amount of EVs that can influence tumor development. Similar to MSC, MSC-EVs can exert both anti- or protumorigenic effects. In the current study, we will investigate the current knowledge related to MSC role in cancer progression with a focus on the MSC-EV content in limiting tumor growth, angiogenesis, and metastasis. We suppose MSC-EVs can be used as safe vehicles for delivering antitumor agents to TME.
间充质干细胞（MSCs）是多能细胞，具有分化为不同细胞类型的潜力。由于其免疫抑制和抗炎特性，它们被广泛应用于再生医学，但它们对癌症进展具有双重作用，对不同类型的癌症表现出生长刺激或抑制作用。有人提出，MSC 在肿瘤微环境（TME）中的这些有争议的作用是通过其向促炎或抗炎表型的极化来介导的。此外，它们还可以使免疫系统细胞极化，从而影响肿瘤的进展。TME 通讯涉及的机制之一是细胞外囊泡（EVs）。MSCs 作为 TME 中的细胞群体之一，会产生大量能够影响肿瘤发展的 EVs。与 MSC 类似，MSC-EVs 可以发挥抗肿瘤或促肿瘤作用。在本研究中，我们将调查与 MSC 在癌症进展中的作用相关的现有知识，重点关注限制肿瘤生长、血管生成和转移的 MSC-EV 含量。我们假设 MSC-EVs 可作为向 TME 递送抗肿瘤药物的安全载体。
